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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EEF1G

Summary for EEF1G

Gene information	Gene symbol	EEF1G
	Ensembl ID	ENSG00000254772
	Entrez ID	1937
	Gene name	eukaryotic translation elongation factor 1 gamma
	Synonyms	EF1G
	Gene type	protein_coding
	UniProtAcc	P26641

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Dataset with differentially expressed gene: EEF1G

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.992675	1.40e-45
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.456783	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.762135	5.09e-08
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.817768	1.06e-29
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.58989	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	0.52492	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.615711	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.252016	6.31e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.325423	3.77e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.510316	4.33e-32
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.281201	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.367609	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	0.316468	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.37287	3.01e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.665172	5.05e-11
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.323068	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	-0.313313	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.360215	1.10e-05
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	post	CD8+ T cells	0.404485	0.00e+00

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Expression of EEF1G in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EEF1G

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EEF1G

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating EEF1G

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EEF1G	transfac_pro__M06355	ZNF841 (directAnnotation).
EEF1G	transfac_pro__M06575	ZNF845 (directAnnotation).
EEF1G	transfac_pro__M06234	ZNF91 (directAnnotation).
EEF1G	swissregulon__mm__Foxc1	FOXC1 (inferredBy_Orthology).
EEF1G	swissregulon__hs__FOXO1	FOXO1 (directAnnotation).
EEF1G	stark__YGATAC	SIX1 (inferredBy_Orthology).
EEF1G	taipale_tf_pairs__ETV2_NHLH1_NGCAGCTGCCGGAWRYN_CAP_repr	ETV2; NHLH1 (directAnnotation).
EEF1G	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
EEF1G	transfac_pro__M05768	ZNF544 (directAnnotation).
EEF1G	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
EEF1G	transfac_pro__M06104	ZNF16 (directAnnotation).
EEF1G	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
EEF1G	metacluster_162.5	NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
EEF1G	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
EEF1G	transfac_pro__M06369	ZFP1 (directAnnotation).
EEF1G	tfdimers__MD00400	CDX2; GFI1; GFI1B (directAnnotation).
EEF1G	metacluster_108.1	ZNF101; ZNF697 (directAnnotation).
EEF1G	metacluster_155.34	PRDM4 (directAnnotation).
EEF1G	metacluster_29.3	BCL6; BCL6; BCL6B; BCL6B (directAnnotation).
EEF1G	transfac_pro__M06404	ZNF497 (directAnnotation).
EEF1G	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EEF1G	transfac_pro__M06626	ZNF558 (directAnnotation).
EEF1G	tfdimers__MD00342	IRF1; YY1 (directAnnotation).
EEF1G	hdpi__TFE3	TFE3 (directAnnotation).
EEF1G	kznf__ZIM2_Imbeault2017_OM_MEME	ZIM2 (directAnnotation).
EEF1G	transfac_pro__M06312	ZNF79 (directAnnotation).
EEF1G	transfac_pro__M05976	ZNF223 (directAnnotation).
EEF1G	transfac_pro__M06964	SALL4 (inferredBy_Orthology).
EEF1G	transfac_public__M00208	NFKB1; RELA (directAnnotation).
EEF1G	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
EEF1G	metacluster_48.4	GFI1; GFI1; GFI1B; GFI1B; GFI1B (directAnnotation). GFI1; GFI1 (inferredBy_Orthology).
EEF1G	taipale_cyt_meth__LHX6_MTCGTTAN_FL_meth	LHX6 (directAnnotation).
EEF1G	transfac_pro__M06284	ZNF74 (directAnnotation).
EEF1G	transfac_pro__M05824	ZBTB49 (directAnnotation).
EEF1G	transfac_pro__M01069	GZF1 (directAnnotation).
EEF1G	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
EEF1G	transfac_pro__M06370	ZNF585A (directAnnotation).
EEF1G	transfac_pro__M06499	ZNF383 (directAnnotation).
EEF1G	tfdimers__MD00059	CRX; NKX2-1 (directAnnotation).
EEF1G	transfac_pro__M06649	ZNF442 (directAnnotation).
EEF1G	transfac_pro__M05829	ZNF627 (directAnnotation).
EEF1G	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
EEF1G	transfac_pro__M05745	ZNF718 (directAnnotation).
EEF1G	metacluster_141.4	GLIS2 (directAnnotation).
EEF1G	transfac_pro__M05642	ZNF879 (directAnnotation).
EEF1G	metacluster_86.6	ZFP3; ZFP3 (directAnnotation).
EEF1G	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGNNNNNNYMATTA_CAP	ETV2; HOXA2 (directAnnotation).
EEF1G	transfac_pro__M06228	ZNF543 (directAnnotation).
EEF1G	swissregulon__hs__HBP1	HBP1 (directAnnotation).
EEF1G	tfdimers__MD00272	ISL1; POU3F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."