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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EED

Summary for EED

Gene information	Gene symbol	EED
	Ensembl ID	ENSG00000074266
	Entrez ID	8726
	Gene name	embryonic ectoderm development
	Synonyms	HEED\|WAIT-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EED

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.301291	2.03e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.428748	0.00e+00

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Expression of EED in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EED

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EED

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EED	hsa-miR-30b-5p	99.5661	NM_001308007
EED	hsa-miR-30c-5p	99.5661	NM_001308007
EED	hsa-miR-30a-5p	99.4882	NM_001308007
EED	hsa-miR-30d-5p	99.4882	NM_001308007
EED	hsa-miR-30e-5p	99.4882	NM_001308007
EED	hsa-miR-524-5p	97.4189	NM_001308007
EED	hsa-miR-520d-5p	97.4189	NM_001308007
EED	hsa-miR-590-3p	94.0432	NM_001308007
EED	hsa-miR-4775	92.2142	NM_001308007
EED	hsa-miR-4735-5p	91.4508	NM_001308007
EED	hsa-miR-197-3p	90.7669	NM_001308007
EED	hsa-miR-548e-5p	90.0577	NM_001308007
EED	hsa-miR-101-3p	89.6613	NM_001308007
EED	hsa-miR-451b	88.5013	NM_001308007
EED	hsa-miR-938	87.206	NM_001308007
EED	hsa-miR-3910	86.3772	NM_001308007
EED	hsa-miR-4661-5p	85.6161	NM_001308007
EED	hsa-miR-4477a	81.0451	NM_001308007

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Motifs and transcription factors (TFs) regulating EED

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EED	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EED	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EED	transfac_pro__M04950	EGR1 (directAnnotation).
EED	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EED	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
EED	transfac_pro__M00652	NRF1 (directAnnotation).
EED	jaspar__MA1122.1	TFDP1 (directAnnotation).
EED	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EED	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
EED	jaspar__MA1708.1	ETV7 (directAnnotation).
EED	jaspar__MA0748.2	YY2 (directAnnotation).
EED	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."