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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ECT2

Summary for ECT2

Gene information	Gene symbol	ECT2
	Ensembl ID	ENSG00000114346
	Entrez ID	1894
	Gene name	epithelial cell transforming 2
	Synonyms	ARHGEF31
	Gene type	protein_coding
	UniProtAcc	Q9H8V3

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Dataset with differentially expressed gene: ECT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.8966	8.00e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.258321	0.00e+00

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Expression of ECT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ECT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ECT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ECT2	hsa-miR-548aw	98.1134	NM_001258316
ECT2	hsa-miR-450b-5p	97.3544	NM_001258316
ECT2	hsa-miR-942-3p	95.7672	NM_001258316
ECT2	hsa-miR-1468-3p	95.7165	NM_001258316
ECT2	hsa-miR-1284	95.2229	NM_001258316
ECT2	hsa-miR-12124	93.0372	NM_001258316
ECT2	hsa-miR-3140-3p	91.773	NM_001258316
ECT2	hsa-miR-8063	91.1869	NM_001258316
ECT2	hsa-miR-4282	90.111	NM_001258316
ECT2	hsa-miR-1253	88.4412	NM_001258316
ECT2	hsa-miR-6849-5p	86.5908	NM_001258316
ECT2	hsa-miR-6509-5p	86.4692	NM_001258316
ECT2	hsa-miR-449c-3p	86.1968	NM_001258316
ECT2	hsa-miR-3681-5p	85.6907	NM_001258316
ECT2	hsa-miR-551b-5p	84.4036	NM_001258316
ECT2	hsa-miR-888-3p	83.9339	NM_001258316
ECT2	hsa-miR-494-3p	83.4295	NM_001258316
ECT2	hsa-miR-518a-5p	83.104	NM_001258316
ECT2	hsa-miR-527	83.104	NM_001258316
ECT2	hsa-miR-520d-5p	82.6839	NM_001258316
ECT2	hsa-miR-524-5p	82.6839	NM_001258316
ECT2	hsa-miR-12136	81.8871	NM_001258316
ECT2	hsa-miR-6839-3p	81.8724	NM_001258316
ECT2	hsa-miR-6715b-3p	81.7239	NM_001258316
ECT2	hsa-miR-548ar-3p	81.3888	NM_001258316
ECT2	hsa-miR-548x-5p	81.0202	NM_001258316
ECT2	hsa-miR-548f-5p	81.0202	NM_001258316
ECT2	hsa-miR-548g-5p	81.0202	NM_001258316
ECT2	hsa-miR-548aj-5p	81.0202	NM_001258316
ECT2	hsa-miR-558	80.9601	NM_001258316

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Motifs and transcription factors (TFs) regulating ECT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ECT2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ECT2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ECT2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ECT2	transfac_pro__M04826	EP300 (directAnnotation).
ECT2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ECT2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ECT2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ECT2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."