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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ECHDC1

Summary for ECHDC1

Gene information	Gene symbol	ECHDC1
	Ensembl ID	ENSG00000093144
	Entrez ID	55862
	Gene name	ethylmalonyl-CoA decarboxylase 1
	Synonyms	dJ351K20.2
	Gene type	protein_coding
	UniProtAcc	Q9NTX5

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Dataset with differentially expressed gene: ECHDC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.315737	1.42e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.345573	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.518494	1.26e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.542285	3.47e-31
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.589506	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.427162	3.05e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.5191	0.00e+00

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Expression of ECHDC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ECHDC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ECHDC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ECHDC1	hsa-miR-889-3p	94.6894	NM_001105544
ECHDC1	hsa-miR-12136	92.9861	NM_001105544
ECHDC1	hsa-miR-526a-5p	92.7834	NM_018479
ECHDC1	hsa-miR-519a-5p	92.7834	NM_018479
ECHDC1	hsa-miR-519c-5p	92.7834	NM_018479
ECHDC1	hsa-miR-518e-5p	92.7834	NM_018479
ECHDC1	hsa-miR-518d-5p	92.7834	NM_018479
ECHDC1	hsa-miR-518f-5p	92.7834	NM_018479
ECHDC1	hsa-miR-522-5p	92.7834	NM_018479
ECHDC1	hsa-miR-520c-5p	92.7834	NM_018479
ECHDC1	hsa-miR-523-5p	92.7834	NM_018479
ECHDC1	hsa-miR-519b-5p	92.7834	NM_018479
ECHDC1	hsa-miR-202-5p	92.3045	NM_018479
ECHDC1	hsa-miR-3614-3p	92.1128	NM_001105544
ECHDC1	hsa-miR-219b-3p	90.5706	NM_018479
ECHDC1	hsa-miR-944	90.3895	NM_018479
ECHDC1	hsa-miR-580-5p	88.9159	NM_001105544
ECHDC1	hsa-miR-548n	87.8134	NM_001105544
ECHDC1	hsa-miR-302c-5p	86.7842	NM_001105544
ECHDC1	hsa-miR-6821-3p	85.5845	NM_018479
ECHDC1	hsa-miR-23a-3p	85.5045	NM_001105544
ECHDC1	hsa-miR-23b-3p	85.5045	NM_001105544
ECHDC1	hsa-miR-23c	85.5045	NM_001105544
ECHDC1	hsa-miR-130b-5p	85.1877	NM_018479
ECHDC1	hsa-miR-877-3p	85.0056	NM_018479
ECHDC1	hsa-miR-3926	84.9171	NM_001105544
ECHDC1	hsa-miR-1252-3p	82.914	NM_001105544
ECHDC1	hsa-miR-4709-5p	82.1658	NM_001105544
ECHDC1	hsa-miR-516b-3p	81.3643	NM_018479
ECHDC1	hsa-miR-516a-3p	81.3643	NM_018479
ECHDC1	hsa-miR-7162-5p	81.3643	NM_018479
ECHDC1	hsa-miR-589-3p	81.3125	NM_001105544
ECHDC1	hsa-miR-3940-5p	81.0314	NM_001105544
ECHDC1	hsa-miR-4507	81.0314	NM_001105544
ECHDC1	hsa-miR-548s	80.4207	NM_001105544
ECHDC1	hsa-miR-6781-3p	80.0405	NM_018479

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Motifs and transcription factors (TFs) regulating ECHDC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ECHDC1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ECHDC1	transfac_pro__M04748	GABPA (directAnnotation).
ECHDC1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ECHDC1	hdpi__TP73	TP73 (directAnnotation).
ECHDC1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ECHDC1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
ECHDC1	hdpi__FLI1	FLI1 (directAnnotation).
ECHDC1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ECHDC1	cisbp__M02645	ETS1 (directAnnotation).
ECHDC1	hdpi__ETV4	ETV4 (directAnnotation).
ECHDC1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
ECHDC1	transfac_pro__M00492	STAT1 (directAnnotation).
ECHDC1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ECHDC1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ECHDC1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ECHDC1	hdpi__ELF2	ELF2 (directAnnotation).
ECHDC1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
ECHDC1	metacluster_183.4	ETS1 (inferredBy_Orthology).
ECHDC1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ECHDC1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ECHDC1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
ECHDC1	transfac_pro__M04848	TAF1 (directAnnotation).
ECHDC1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."