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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EBF3

Summary for EBF3

Gene information	Gene symbol	EBF3
	Ensembl ID	ENSG00000108001
	Entrez ID	253738
	Gene name	EBF transcription factor 3
	Synonyms	COE3\|DKFZp667B0210
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EBF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.284559	0.00e+00

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Expression of EBF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EBF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EBF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EBF3	hsa-miR-8060	98.6124	NM_001005463
EBF3	hsa-miR-650	98.5041	NM_001005463
EBF3	hsa-miR-3612	98.5041	NM_001005463
EBF3	hsa-miR-7154-5p	97.9325	NM_001005463
EBF3	hsa-miR-621	96.7616	NM_001005463
EBF3	hsa-miR-1206	96.5675	NM_001005463
EBF3	hsa-miR-3662	96.315	NM_001005463
EBF3	hsa-miR-3688-5p	96.2875	NM_001005463
EBF3	hsa-miR-3613-3p	95.436	NM_001005463
EBF3	hsa-miR-4470	94.7669	NM_001005463
EBF3	hsa-miR-4443	94.6896	NM_001005463
EBF3	hsa-miR-5195-3p	94.6517	NM_001005463
EBF3	hsa-miR-145-5p	94.6517	NM_001005463
EBF3	hsa-miR-3163	94.2876	NM_001005463
EBF3	hsa-miR-636	94.1171	NM_001005463
EBF3	hsa-miR-23c	94.0531	NM_001005463
EBF3	hsa-miR-23a-3p	94.0531	NM_001005463
EBF3	hsa-miR-23b-3p	94.0531	NM_001005463
EBF3	hsa-miR-218-5p	93.8086	NM_001005463
EBF3	hsa-miR-1185-2-3p	93.6994	NM_001005463
EBF3	hsa-miR-1185-1-3p	93.6994	NM_001005463
EBF3	hsa-let-7f-2-3p	93.6994	NM_001005463
EBF3	hsa-miR-96-5p	93.1685	NM_001005463
EBF3	hsa-miR-95-5p	93.1004	NM_001005463
EBF3	hsa-let-7f-1-3p	92.5722	NM_001005463
EBF3	hsa-let-7b-3p	92.5722	NM_001005463
EBF3	hsa-miR-98-3p	92.5722	NM_001005463
EBF3	hsa-let-7a-3p	92.5722	NM_001005463
EBF3	hsa-miR-524-5p	92.4977	NM_001005463
EBF3	hsa-miR-520d-5p	92.4977	NM_001005463
EBF3	hsa-miR-4302	92.3551	NM_001005463
EBF3	hsa-miR-93-3p	92.3162	NM_001005463
EBF3	hsa-miR-4667-3p	92.1318	NM_001005463
EBF3	hsa-miR-4694-3p	92.0296	NM_001005463
EBF3	hsa-miR-12117	91.5584	NM_001005463
EBF3	hsa-miR-12133	91.5564	NM_001005463
EBF3	hsa-miR-1271-5p	91.5564	NM_001005463
EBF3	hsa-miR-573	91.1806	NM_001005463
EBF3	hsa-miR-3616-5p	91.1806	NM_001005463
EBF3	hsa-miR-605-3p	91.0289	NM_001005463
EBF3	hsa-miR-338-5p	90.6085	NM_001005463
EBF3	hsa-miR-4799-5p	90.3525	NM_001005463
EBF3	hsa-miR-5585-5p	89.7405	NM_001005463
EBF3	hsa-miR-6071	89.0618	NM_001005463
EBF3	hsa-miR-3646	88.7975	NM_001005463
EBF3	hsa-miR-6739-5p	88.2465	NM_001005463
EBF3	hsa-miR-6733-5p	88.2465	NM_001005463
EBF3	hsa-miR-519e-5p	87.9531	NM_001005463
EBF3	hsa-miR-515-5p	87.9531	NM_001005463
EBF3	hsa-miR-582-5p	87.7545	NM_001005463

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Motifs and transcription factors (TFs) regulating EBF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EBF3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EBF3	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."