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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EBAG9

Summary for EBAG9

Gene information	Gene symbol	EBAG9
	Ensembl ID	ENSG00000147654
	Entrez ID	9166
	Gene name	estrogen receptor binding site associated antigen 9
	Synonyms	EB9\|RCAS1
	Gene type	protein_coding
	UniProtAcc	O00559

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Dataset with differentially expressed gene: EBAG9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.480337	7.11e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.376777	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.267643	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.288106	0.00e+00

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Expression of EBAG9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EBAG9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EBAG9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EBAG9	hsa-miR-887-5p	93.8559	NM_001278938
EBAG9	hsa-miR-4261	93.8547	NM_001278938
EBAG9	hsa-miR-409-3p	93.0827	NM_001278938
EBAG9	hsa-miR-147b-5p	92.7524	NM_001278938
EBAG9	hsa-miR-6740-3p	88.3984	NM_001278938
EBAG9	hsa-miR-1250-3p	87.7057	NM_001278938
EBAG9	hsa-miR-6788-5p	87.4195	NM_001278938
EBAG9	hsa-miR-944	87.2586	NM_001278938
EBAG9	hsa-miR-3689b-5p	86.512	NM_001278938
EBAG9	hsa-miR-3689a-5p	86.512	NM_001278938
EBAG9	hsa-miR-3689e	86.512	NM_001278938
EBAG9	hsa-miR-3689f	86.512	NM_001278938
EBAG9	hsa-miR-6780a-5p	85.0916	NM_001278938
EBAG9	hsa-miR-627-5p	84.701	NM_001278938
EBAG9	hsa-miR-8081	84.3339	NM_001278938
EBAG9	hsa-miR-7154-5p	83.863	NM_001278938
EBAG9	hsa-miR-3120-3p	83.2836	NM_001278938
EBAG9	hsa-miR-33a-3p	82.8518	NM_001278938
EBAG9	hsa-miR-1260a	82.8305	NM_001278938
EBAG9	hsa-miR-1260b	82.8305	NM_001278938
EBAG9	hsa-miR-3689b-3p	82.4336	NM_001278938
EBAG9	hsa-miR-1273h-5p	82.4336	NM_001278938
EBAG9	hsa-miR-3689c	82.4336	NM_001278938
EBAG9	hsa-miR-3689a-3p	82.4336	NM_001278938
EBAG9	hsa-miR-30b-3p	82.4336	NM_001278938
EBAG9	hsa-miR-6779-5p	82.4336	NM_001278938
EBAG9	hsa-miR-30c-1-3p	81.5953	NM_001278938
EBAG9	hsa-miR-30c-2-3p	81.5953	NM_001278938
EBAG9	hsa-miR-4489	81.3504	NM_001278938
EBAG9	hsa-miR-3163	81.3343	NM_001278938
EBAG9	hsa-miR-4666a-5p	81.2176	NM_001278938
EBAG9	hsa-miR-4720-5p	80.6242	NM_001278938
EBAG9	hsa-miR-4799-3p	80.6242	NM_001278938
EBAG9	hsa-miR-5588-5p	80.6242	NM_001278938
EBAG9	hsa-miR-1224-3p	80.457	NM_001278938
EBAG9	hsa-miR-499a-5p	80.0593	NM_001278938

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Motifs and transcription factors (TFs) regulating EBAG9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EBAG9	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
EBAG9	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
EBAG9	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
EBAG9	cisbp__M02645	ETS1 (directAnnotation).
EBAG9	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
EBAG9	cisbp__M08198	ELF1 (directAnnotation).
EBAG9	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
EBAG9	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
EBAG9	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
EBAG9	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
EBAG9	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
EBAG9	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
EBAG9	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EBAG9	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EBAG9	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
EBAG9	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
EBAG9	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
EBAG9	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
EBAG9	transfac_pro__M00652	NRF1 (directAnnotation).
EBAG9	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EBAG9	transfac_pro__M04866	HDAC2 (directAnnotation).
EBAG9	jaspar__MA1122.1	TFDP1 (directAnnotation).
EBAG9	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EBAG9	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
EBAG9	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
EBAG9	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
EBAG9	transfac_pro__M04794	TAF1 (directAnnotation).
EBAG9	transfac_pro__M04862	NRF1 (directAnnotation).
EBAG9	jaspar__MA0748.2	YY2 (directAnnotation).
EBAG9	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
EBAG9	transfac_pro__M04748	GABPA (directAnnotation).
EBAG9	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
EBAG9	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
EBAG9	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
EBAG9	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."