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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: E2F6

Summary for E2F6

Gene information	Gene symbol	E2F6
	Ensembl ID	ENSG00000169016
	Entrez ID	1876
	Gene name	E2F transcription factor 6
	Synonyms	E2F-6
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: E2F6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.281802	1.86e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.284812	6.55e-23

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Expression of E2F6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to E2F6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
E2F6	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating E2F6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
E2F6	hsa-miR-607	98.7311	NM_198256
E2F6	hsa-miR-589-3p	94.7742	NM_198256
E2F6	hsa-miR-5691	94.5762	NM_001278275
E2F6	hsa-miR-6805-3p	94.5762	NM_001278275
E2F6	hsa-miR-3671	94.4806	NM_198256
E2F6	hsa-miR-4500	93.6242	NM_001278275
E2F6	hsa-let-7f-2-3p	91.8108	NM_198256
E2F6	hsa-miR-1185-2-3p	91.8108	NM_198256
E2F6	hsa-miR-1185-1-3p	91.8108	NM_198256
E2F6	hsa-miR-5571-5p	91.6963	NM_001278275
E2F6	hsa-miR-513b-5p	91.5593	NM_198256
E2F6	hsa-let-7a-5p	91.1301	NM_001278275
E2F6	hsa-let-7f-5p	91.1301	NM_001278275
E2F6	hsa-let-7i-5p	91.1301	NM_001278275
E2F6	hsa-let-7c-5p	91.1301	NM_001278275
E2F6	hsa-miR-98-5p	91.1301	NM_001278275
E2F6	hsa-let-7b-5p	91.1301	NM_001278275
E2F6	hsa-let-7e-5p	91.1301	NM_001278275
E2F6	hsa-let-7g-5p	91.1301	NM_001278275
E2F6	hsa-miR-548e-5p	90.5683	NM_198256
E2F6	hsa-let-7d-5p	90.0173	NM_001278275
E2F6	hsa-miR-4458	90.0173	NM_001278275
E2F6	hsa-miR-137-3p	89.8386	NM_001278275
E2F6	hsa-miR-548ap-3p	88.6406	NM_198256
E2F6	hsa-miR-548t-3p	88.6406	NM_198256
E2F6	hsa-miR-548aa	88.6406	NM_198256
E2F6	hsa-miR-4251	87.7781	NM_198256
E2F6	hsa-miR-138-2-3p	84.5067	NM_198256
E2F6	hsa-miR-7157-5p	84.332	NM_198256
E2F6	hsa-miR-4310	83.9004	NM_198256
E2F6	hsa-miR-576-5p	83.6958	NM_198256
E2F6	hsa-miR-4695-3p	83.5767	NM_198256
E2F6	hsa-miR-4420	83.222	NM_198256
E2F6	hsa-miR-181b-3p	83.222	NM_198256
E2F6	hsa-miR-181b-2-3p	83.222	NM_198256
E2F6	hsa-miR-125b-2-3p	82.3564	NM_198256
E2F6	hsa-miR-6864-5p	81.1688	NM_198256

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Motifs and transcription factors (TFs) regulating E2F6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
E2F6	metacluster_151.2	ZNF23 (directAnnotation).
E2F6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
E2F6	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
E2F6	metacluster_135.11	NR2C2 (directAnnotation).
E2F6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
E2F6	cisbp__M00968	MTF2 (directAnnotation).
E2F6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
E2F6	cisbp__M00341	PAX6 (directAnnotation).
E2F6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
E2F6	metacluster_55.3	down	Malignant cells	GSE175716	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."