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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DYNC1LI2

Summary for DYNC1LI2

Gene information	Gene symbol	DYNC1LI2
	Ensembl ID	ENSG00000135720
	Entrez ID	1783
	Gene name	dynein cytoplasmic 1 light intermediate chain 2
	Synonyms	DNCLI2
	Gene type	protein_coding
	UniProtAcc	O43237

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Dataset with differentially expressed gene: DYNC1LI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.478135	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.311779	5.67e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.263204	2.92e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.317991	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.325026	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.290893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.285038	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.281007	0.00e+00

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Expression of DYNC1LI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DYNC1LI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DYNC1LI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DYNC1LI2	hsa-miR-519d-3p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-106a-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-93-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-106b-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-526b-3p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-20a-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-20b-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-17-5p	99.8813	NM_001323955
DYNC1LI2	hsa-miR-3163	98.8566	NM_001323955
DYNC1LI2	hsa-miR-4282	98.3892	NM_001323955
DYNC1LI2	hsa-miR-548t-5p	98.2066	NM_001323955
DYNC1LI2	hsa-miR-548az-5p	98.2066	NM_001323955
DYNC1LI2	hsa-miR-130a-3p	97.6098	NM_001323955
DYNC1LI2	hsa-miR-3666	97.1708	NM_001323955
DYNC1LI2	hsa-miR-130b-3p	97.1708	NM_001323955
DYNC1LI2	hsa-miR-4295	97.1708	NM_001323955
DYNC1LI2	hsa-miR-301a-3p	97.1708	NM_001323955
DYNC1LI2	hsa-miR-454-3p	97.1708	NM_001323955
DYNC1LI2	hsa-miR-301b-3p	97.1708	NM_001323955
DYNC1LI2	hsa-miR-543	97.1063	NM_001323955
DYNC1LI2	hsa-miR-548aj-3p	96.8272	NM_006141
DYNC1LI2	hsa-miR-548x-3p	96.8272	NM_006141
DYNC1LI2	hsa-miR-33a-5p	96.6442	NM_006141
DYNC1LI2	hsa-miR-33b-5p	96.6442	NM_006141
DYNC1LI2	hsa-miR-3667-3p	96.1163	NM_006141
DYNC1LI2	hsa-miR-4786-3p	95.8979	NM_001323955
DYNC1LI2	hsa-miR-548ah-3p	95.494	NM_006141
DYNC1LI2	hsa-miR-548aq-3p	95.494	NM_006141
DYNC1LI2	hsa-miR-548ae-3p	95.494	NM_006141
DYNC1LI2	hsa-miR-548j-3p	95.494	NM_006141
DYNC1LI2	hsa-miR-548am-3p	95.494	NM_006141
DYNC1LI2	hsa-miR-7843-3p	95.4591	NM_001323955
DYNC1LI2	hsa-miR-519a-3p	95.2672	NM_001323955
DYNC1LI2	hsa-miR-519c-3p	95.2672	NM_001323955
DYNC1LI2	hsa-miR-519b-3p	95.2672	NM_001323955
DYNC1LI2	hsa-miR-4274	95.0876	NM_001323955
DYNC1LI2	hsa-miR-548ar-3p	94.1662	NM_006141
DYNC1LI2	hsa-miR-548f-3p	93.7587	NM_006141
DYNC1LI2	hsa-miR-548bc	93.7587	NM_006141
DYNC1LI2	hsa-miR-548az-3p	93.7587	NM_006141
DYNC1LI2	hsa-miR-548e-3p	93.7587	NM_006141
DYNC1LI2	hsa-miR-548a-3p	93.7587	NM_006141
DYNC1LI2	hsa-miR-4310	93.6723	NM_001323955
DYNC1LI2	hsa-miR-5699-5p	92.8099	NM_006141
DYNC1LI2	hsa-miR-4524a-5p	92.1763	NM_001323955
DYNC1LI2	hsa-miR-4524b-5p	92.1763	NM_001323955
DYNC1LI2	hsa-miR-2115-3p	92.1759	NM_006141
DYNC1LI2	hsa-miR-12136	91.6476	NM_001323955
DYNC1LI2	hsa-miR-7157-5p	91.3962	NM_001323955
DYNC1LI2	hsa-miR-127-5p	91.152	NM_001323955

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Motifs and transcription factors (TFs) regulating DYNC1LI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DYNC1LI2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DYNC1LI2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
DYNC1LI2	transfac_pro__M01299	MECP2 (directAnnotation).
DYNC1LI2	transfac_pro__M06035	ZNF749 (directAnnotation).
DYNC1LI2	metacluster_143.14	ZNF320 (directAnnotation).
DYNC1LI2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DYNC1LI2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
DYNC1LI2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
DYNC1LI2	jaspar__MA0748.2	YY2 (directAnnotation).
DYNC1LI2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
DYNC1LI2	metacluster_198.3	ZFP64 (directAnnotation).
DYNC1LI2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DYNC1LI2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."