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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DUSP3

Summary for DUSP3

Gene information	Gene symbol	DUSP3
	Ensembl ID	ENSG00000108861
	Entrez ID	1845
	Gene name	dual specificity phosphatase 3
	Synonyms	VHR
	Gene type	protein_coding
	UniProtAcc	P51452

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Dataset with differentially expressed gene: DUSP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.376117	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.28113	1.05e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.285939	1.23e-16

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Expression of DUSP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DUSP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DUSP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DUSP3	hsa-miR-200a-3p	98.7438	NM_004090
DUSP3	hsa-miR-141-3p	98.7438	NM_004090
DUSP3	hsa-miR-6740-3p	92.2574	NM_004090
DUSP3	hsa-miR-92a-2-5p	91.7311	NM_004090
DUSP3	hsa-miR-3617-5p	90.7078	NM_004090
DUSP3	hsa-miR-641	90.7078	NM_004090
DUSP3	hsa-miR-4450	88.266	NM_004090
DUSP3	hsa-miR-3907	88.0951	NM_004090
DUSP3	hsa-miR-4441	87.4198	NM_004090
DUSP3	hsa-miR-6857-3p	87.0299	NM_004090
DUSP3	hsa-miR-515-5p	84.9704	NM_004090
DUSP3	hsa-miR-519e-5p	84.9704	NM_004090
DUSP3	hsa-miR-196a-3p	84.2116	NM_004090
DUSP3	hsa-miR-616-5p	83.9552	NM_004090
DUSP3	hsa-miR-373-5p	83.9552	NM_004090
DUSP3	hsa-miR-371b-5p	83.9552	NM_004090
DUSP3	hsa-miR-4743-3p	83.7393	NM_004090
DUSP3	hsa-miR-4270	83.5366	NM_004090
DUSP3	hsa-miR-103a-1-5p	82.709	NM_004090
DUSP3	hsa-miR-103a-2-5p	82.709	NM_004090
DUSP3	hsa-miR-504-5p	82.1163	NM_004090
DUSP3	hsa-miR-4725-5p	82.1163	NM_004090
DUSP3	hsa-miR-186-3p	82.0195	NM_004090
DUSP3	hsa-miR-5000-3p	81.6886	NM_004090
DUSP3	hsa-miR-153-3p	81.2032	NM_004090
DUSP3	hsa-miR-5002-5p	80.8835	NM_004090
DUSP3	hsa-miR-506-3p	80.5759	NM_004090
DUSP3	hsa-miR-124-3p	80.5759	NM_004090
DUSP3	hsa-miR-6754-5p	80.1599	NM_004090

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Motifs and transcription factors (TFs) regulating DUSP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DUSP3	metacluster_198.3	ZFP64 (directAnnotation).
DUSP3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."