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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DUSP16

Summary for DUSP16

Gene information	Gene symbol	DUSP16
	Ensembl ID	ENSG00000280962
	Entrez ID	80824
	Gene name	dual specificity phosphatase 16
	Synonyms	KIAA1700\|MKP-7\|MKP7
	Gene type	protein_coding
	UniProtAcc	Q9BY84

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Dataset with differentially expressed gene: DUSP16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.414659	2.38e-17
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.455083	3.70e-26

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Expression of DUSP16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DUSP16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DUSP16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DUSP16	hsa-miR-5011-5p	99.3119	NM_030640
DUSP16	hsa-miR-2113	98.019	NM_030640
DUSP16	hsa-miR-4420	97.704	NM_030640
DUSP16	hsa-miR-181b-3p	97.6904	NM_030640
DUSP16	hsa-miR-181b-2-3p	97.6904	NM_030640
DUSP16	hsa-miR-190a-3p	96.4833	NM_030640
DUSP16	hsa-miR-7152-5p	96.4719	NM_030640
DUSP16	hsa-miR-4496	95.5749	NM_030640
DUSP16	hsa-miR-320a-3p	94.7391	NM_030640
DUSP16	hsa-miR-320b	94.7391	NM_030640
DUSP16	hsa-miR-320d	94.7391	NM_030640
DUSP16	hsa-miR-320c	94.7391	NM_030640
DUSP16	hsa-miR-4429	94.7391	NM_030640
DUSP16	hsa-miR-3942-3p	94.1393	NM_030640
DUSP16	hsa-miR-3133	93.6838	NM_030640
DUSP16	hsa-miR-205-3p	93.4261	NM_030640
DUSP16	hsa-miR-7162-3p	92.1115	NM_030640
DUSP16	hsa-miR-493-5p	91.825	NM_030640
DUSP16	hsa-miR-12123	91.4054	NM_030640
DUSP16	hsa-miR-1253	91.3432	NM_030640
DUSP16	hsa-miR-6886-3p	90.9366	NM_030640
DUSP16	hsa-miR-302c-5p	90.1417	NM_030640
DUSP16	hsa-miR-6867-5p	88.758	NM_030640
DUSP16	hsa-miR-6515-3p	87.6635	NM_030640
DUSP16	hsa-miR-105-5p	87.5626	NM_030640
DUSP16	hsa-miR-7853-5p	87.5626	NM_030640
DUSP16	hsa-miR-12119	87.3234	NM_030640
DUSP16	hsa-miR-4530	87.2315	NM_030640
DUSP16	hsa-miR-5010-3p	86.4633	NM_030640
DUSP16	hsa-miR-6131	85.4731	NM_030640
DUSP16	hsa-miR-1299	85.4505	NM_030640
DUSP16	hsa-miR-24-3p	84.904	NM_030640
DUSP16	hsa-miR-3658	84.8408	NM_030640
DUSP16	hsa-miR-4796-5p	83.6899	NM_030640
DUSP16	hsa-miR-6074	83.6473	NM_030640
DUSP16	hsa-miR-6508-5p	83.4636	NM_030640
DUSP16	hsa-miR-4261	83.0784	NM_030640
DUSP16	hsa-miR-4698	83.0319	NM_030640
DUSP16	hsa-miR-7151-3p	83.0172	NM_030640
DUSP16	hsa-miR-8067	82.6922	NM_030640
DUSP16	hsa-miR-3202	82.6766	NM_030640
DUSP16	hsa-miR-1277-5p	82.5797	NM_030640
DUSP16	hsa-miR-3923	82.2442	NM_030640
DUSP16	hsa-miR-4251	80.5177	NM_030640
DUSP16	hsa-miR-338-3p	80.3538	NM_030640
DUSP16	hsa-miR-297	80.3333	NM_030640
DUSP16	hsa-miR-942-5p	80.1652	NM_030640

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Motifs and transcription factors (TFs) regulating DUSP16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DUSP16	cisbp__M01174	OSR1 (inferredBy_Orthology).
DUSP16	transfac_pro__M06104	ZNF16 (directAnnotation).
DUSP16	metacluster_23.5	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."