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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DUSP10

Summary for DUSP10

Gene information	Gene symbol	DUSP10
	Ensembl ID	ENSG00000143507
	Entrez ID	11221
	Gene name	dual specificity phosphatase 10
	Synonyms	MKP-5\|MKP5
	Gene type	protein_coding
	UniProtAcc	Q9Y6W6

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Dataset with differentially expressed gene: DUSP10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.39095	1.19e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.593901	1.47e-36
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.608272	7.29e-43
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.407226	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.442416	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.523808	1.29e-37

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Expression of DUSP10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DUSP10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DUSP10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DUSP10	hsa-miR-651-3p	99.3731	NM_007207
DUSP10	hsa-miR-1283	97.7071	NM_007207
DUSP10	hsa-miR-1252-5p	97.3521	NM_007207
DUSP10	hsa-miR-659-3p	95.7596	NM_007207
DUSP10	hsa-miR-4729	95.6948	NM_007207
DUSP10	hsa-miR-6770-5p	94.8159	NM_007207
DUSP10	hsa-miR-8064	94.81	NM_007207
DUSP10	hsa-miR-411-3p	94.6746	NM_007207
DUSP10	hsa-miR-379-3p	94.6746	NM_007207
DUSP10	hsa-miR-4642	94.381	NM_007207
DUSP10	hsa-miR-450a-5p	93.8875	NM_007207
DUSP10	hsa-miR-605-3p	92.4733	NM_007207
DUSP10	hsa-miR-624-3p	91.3035	NM_007207
DUSP10	hsa-miR-5196-5p	90.9583	NM_007207
DUSP10	hsa-miR-4747-5p	90.9583	NM_007207
DUSP10	hsa-miR-9851-5p	90.926	NM_007207
DUSP10	hsa-miR-2115-3p	90.5368	NM_007207
DUSP10	hsa-miR-3148	90.292	NM_007207
DUSP10	hsa-miR-3613-3p	90.0972	NM_007207
DUSP10	hsa-miR-92a-3p	89.9911	NM_007207
DUSP10	hsa-miR-32-5p	89.9911	NM_007207
DUSP10	hsa-miR-92b-3p	89.9911	NM_007207
DUSP10	hsa-miR-5580-3p	89.9144	NM_007207
DUSP10	hsa-miR-519a-2-5p	89.6657	NM_007207
DUSP10	hsa-miR-520b-5p	89.6657	NM_007207
DUSP10	hsa-miR-183-5p	89.1748	NM_007207
DUSP10	hsa-miR-5696	89.0252	NM_007207
DUSP10	hsa-miR-8485	88.8035	NM_007207
DUSP10	hsa-miR-4533	88.1834	NM_007207
DUSP10	hsa-miR-137-3p	87.3608	NM_007207
DUSP10	hsa-miR-363-3p	86.9393	NM_007207
DUSP10	hsa-miR-25-3p	86.9393	NM_007207
DUSP10	hsa-miR-367-3p	86.9393	NM_007207
DUSP10	hsa-miR-4762-3p	86.6501	NM_007207
DUSP10	hsa-miR-6083	86.445	NM_007207
DUSP10	hsa-miR-362-3p	86.0486	NM_007207
DUSP10	hsa-miR-329-3p	86.0486	NM_007207
DUSP10	hsa-miR-548c-3p	84.6305	NM_007207
DUSP10	hsa-miR-138-2-3p	84.4229	NM_007207
DUSP10	hsa-miR-9983-3p	84.0147	NM_007207
DUSP10	hsa-miR-618	82.9795	NM_007207
DUSP10	hsa-miR-8063	82.8754	NM_007207
DUSP10	hsa-miR-129-5p	81.6843	NM_007207
DUSP10	hsa-miR-4267	81.6741	NM_007207
DUSP10	hsa-miR-6870-5p	80.9294	NM_007207
DUSP10	hsa-miR-7111-5p	80.9294	NM_007207
DUSP10	hsa-miR-5698	80.9294	NM_007207
DUSP10	hsa-miR-4723-5p	80.9294	NM_007207

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Motifs and transcription factors (TFs) regulating DUSP10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DUSP10	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DUSP10	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
DUSP10	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DUSP10	transfac_pro__M04617	ZBTB7A (directAnnotation).
DUSP10	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DUSP10	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DUSP10	transfac_pro__M07387	ZBTB7A (directAnnotation).
DUSP10	transfac_pro__M07436	WT1 (directAnnotation).
DUSP10	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DUSP10	transfac_pro__M00716	ZBTB14 (directAnnotation).
DUSP10	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DUSP10	hdpi__HIP2	UBE2K (directAnnotation).
DUSP10	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DUSP10	transfac_pro__M04893	TAF1 (directAnnotation).
DUSP10	transfac_pro__M03876	ZBTB33 (directAnnotation).
DUSP10	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DUSP10	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DUSP10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DUSP10	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
DUSP10	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
DUSP10	transfac_pro__M01783	SP2 (directAnnotation).
DUSP10	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DUSP10	cisbp__M00341	PAX6 (directAnnotation).
DUSP10	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DUSP10	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
DUSP10	transfac_pro__M01253	CNOT3 (directAnnotation).
DUSP10	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DUSP10	metacluster_7.13	ZFX (directAnnotation).
DUSP10	cisbp__M00968	MTF2 (directAnnotation).
DUSP10	transfac_pro__M04817	ZBTB33 (directAnnotation).
DUSP10	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DUSP10	transfac_pro__M02089	E2F3 (directAnnotation).
DUSP10	jaspar__MA0748.2	YY2 (directAnnotation).
DUSP10	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
DUSP10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DUSP10	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DUSP10	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DUSP10	metacluster_198.3	ZFP64 (directAnnotation).
DUSP10	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DUSP10	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DUSP10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DUSP10	cisbp__M00788	ZFY (inferredBy_Orthology).
DUSP10	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DUSP10	metacluster_175.1	ZNF283 (directAnnotation).
DUSP10	hdpi__ZNF304	ZNF304 (directAnnotation).
DUSP10	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DUSP10	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DUSP10	transfac_pro__M01199	TRIM28 (directAnnotation).
DUSP10	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DUSP10	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."