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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: DUOXA1

Summary for DUOXA1

Gene informationGene symbol

DUOXA1

Ensembl ID

ENSG00000140254

Entrez ID

90527

Gene namedual oxidase maturation factor 1
SynonymsFLJ32334|mol|NIP|NUMBIP
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: DUOXA1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.3098563.90e-17

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Expression of DUOXA1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to DUOXA1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DUOXA1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
DUOXA1hsa-miR-568394.9426NM_001276265
DUOXA1hsa-miR-570387.1691NM_001276267
DUOXA1hsa-miR-451687.1691NM_001276267
DUOXA1hsa-miR-3692-5p86.74NM_001276267
DUOXA1hsa-miR-4708-3p84.9498NM_001276267
DUOXA1hsa-miR-3928-5p83.4756NM_001276267
DUOXA1hsa-miR-6806-3p83.4756NM_001276267
DUOXA1hsa-miR-3925-3p82.712NM_001276268
DUOXA1hsa-miR-6815-5p81.9724NM_001276267
DUOXA1hsa-miR-6865-5p81.9724NM_001276267
DUOXA1hsa-miR-607181.68NM_001276267
DUOXA1hsa-miR-443480.0799NM_001276267
Page: 1

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Motifs and transcription factors (TFs) regulating DUOXA1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
DUOXA1metacluster_175.5IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."