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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DSG2

Summary for DSG2

Gene information	Gene symbol	DSG2
	Ensembl ID	ENSG00000046604
	Entrez ID	1829
	Gene name	desmoglein 2
	Synonyms	CDHF5
	Gene type	protein_coding
	UniProtAcc	Q14126

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Dataset with differentially expressed gene: DSG2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.716726	8.71e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.49976	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.330618	3.36e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.380655	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.468567	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.512948	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.15506	0.00e+00

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Expression of DSG2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DSG2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
DSG2	Malignant cells	CPI-SS0B6F0C894	DSG2_DSC3	DSG2	DSC3	False	Malignant cells	Malignant cells	GSE207422_Tor	post	resistant
DSG2	Malignant cells	CPI-SS0B6F0C894	DSG2_DSC3	DSG2	DSC3	False	Fibroblasts	Malignant cells	GSE207422_Tor	post	sensitive
DSG2	Malignant cells	CPI-SS0B6F0C894	DSG2_DSC3	DSG2	DSC3	False	Malignant cells	Malignant cells	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DSG2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DSG2	hsa-miR-548ar-3p	96.5574	NM_001943
DSG2	hsa-miR-548az-3p	96.5043	NM_001943
DSG2	hsa-miR-548e-3p	95.7859	NM_001943
DSG2	hsa-miR-548bc	95.7859	NM_001943
DSG2	hsa-miR-548a-3p	95.7859	NM_001943
DSG2	hsa-miR-548f-3p	95.7859	NM_001943
DSG2	hsa-miR-374a-5p	95.3416	NM_001943
DSG2	hsa-miR-12132	94.7533	NM_001943
DSG2	hsa-miR-374b-5p	94.5667	NM_001943
DSG2	hsa-miR-30c-5p	94.4297	NM_001943
DSG2	hsa-miR-30b-5p	94.4297	NM_001943
DSG2	hsa-miR-30a-5p	94.4297	NM_001943
DSG2	hsa-miR-30e-5p	94.4297	NM_001943
DSG2	hsa-miR-30d-5p	94.4297	NM_001943
DSG2	hsa-miR-510-3p	94.0615	NM_001943
DSG2	hsa-miR-98-3p	93.1803	NM_001943
DSG2	hsa-let-7b-3p	93.1803	NM_001943
DSG2	hsa-let-7a-3p	93.1803	NM_001943
DSG2	hsa-miR-5692b	92.9045	NM_001943
DSG2	hsa-miR-5692c	92.9045	NM_001943
DSG2	hsa-miR-1283	92.0042	NM_001943
DSG2	hsa-let-7f-1-3p	91.7881	NM_001943
DSG2	hsa-miR-539-5p	91.7456	NM_001943
DSG2	hsa-miR-224-5p	91.0159	NM_001943
DSG2	hsa-miR-5582-3p	90.6203	NM_001943
DSG2	hsa-miR-590-3p	90.1679	NM_001943
DSG2	hsa-miR-1468-3p	89.1531	NM_001943
DSG2	hsa-miR-3121-5p	88.5723	NM_001943
DSG2	hsa-miR-506-3p	87.9974	NM_001943
DSG2	hsa-miR-124-3p	87.9974	NM_001943
DSG2	hsa-miR-499a-5p	87.1261	NM_001943
DSG2	hsa-miR-494-3p	86.8885	NM_001943
DSG2	hsa-miR-4251	86.5264	NM_001943
DSG2	hsa-miR-873-5p	85.0993	NM_001943
DSG2	hsa-miR-1272	85.0372	NM_001943
DSG2	hsa-miR-4796-5p	84.8775	NM_001943
DSG2	hsa-miR-6857-3p	83.3755	NM_001943
DSG2	hsa-miR-182-5p	82.6184	NM_001943
DSG2	hsa-miR-369-3p	82.088	NM_001943
DSG2	hsa-miR-4682	81.9762	NM_001943
DSG2	hsa-miR-5190	81.8246	NM_001943
DSG2	hsa-miR-548p	81.6326	NM_001943
DSG2	hsa-miR-5094	81.0811	NM_001943

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Motifs and transcription factors (TFs) regulating DSG2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DSG2	metacluster_7.13	ZFX (directAnnotation).
DSG2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DSG2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
DSG2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DSG2	metacluster_151.2	ZNF23 (directAnnotation).
DSG2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DSG2	transfac_pro__M05479	ZNF580 (directAnnotation).
DSG2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DSG2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
DSG2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DSG2	transfac_pro__M05628	ZNF735 (directAnnotation).
DSG2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DSG2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
DSG2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DSG2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
DSG2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
DSG2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
DSG2	jaspar__MA1122.1	TFDP1 (directAnnotation).
DSG2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
DSG2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DSG2	transfac_pro__M04617	ZBTB7A (directAnnotation).
DSG2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DSG2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DSG2	transfac_pro__M07387	ZBTB7A (directAnnotation).
DSG2	transfac_pro__M07436	WT1 (directAnnotation).
DSG2	transfac_pro__M00716	ZBTB14 (directAnnotation).
DSG2	hdpi__HIP2	UBE2K (directAnnotation).
DSG2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DSG2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DSG2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DSG2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DSG2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
DSG2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DSG2	cisbp__M00968	MTF2 (directAnnotation).
DSG2	cisbp__M00341	PAX6 (directAnnotation).
DSG2	metacluster_198.3	ZFP64 (directAnnotation).
DSG2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DSG2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DSG2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DSG2	cisbp__M00788	ZFY (inferredBy_Orthology).
DSG2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DSG2	metacluster_175.1	ZNF283 (directAnnotation).
DSG2	hdpi__ZNF304	ZNF304 (directAnnotation).
DSG2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DSG2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DSG2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DSG2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DSG2	transfac_pro__M03806	ZBTB7C (directAnnotation).
DSG2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DSG2	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."