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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DSE

Summary for DSE

Gene information	Gene symbol	DSE
	Ensembl ID	ENSG00000111817
	Entrez ID	29940
	Gene name	dermatan sulfate epimerase
	Synonyms	DS-Epi1\|DSEPI\|SART2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DSE

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.333523	8.58e-20
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.741432	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.293649	4.21e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.583585	0.00e+00

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Expression of DSE in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DSE

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DSE

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DSE	hsa-miR-3692-3p	97.7641	NM_001322943
DSE	hsa-miR-9-5p	97.069	NM_001322943
DSE	hsa-miR-587	96.8786	NM_001322944
DSE	hsa-miR-9983-3p	96.1798	NM_013352
DSE	hsa-miR-4279	96.1777	NM_001322943
DSE	hsa-miR-6844	96.0502	NM_001322943
DSE	hsa-miR-651-3p	95.4918	NM_001322943
DSE	hsa-miR-4712-5p	94.9852	NM_001322943
DSE	hsa-miR-770-5p	94.9852	NM_001322943
DSE	hsa-miR-4482-3p	94.9272	NM_013352
DSE	hsa-miR-129-5p	93.6714	NM_013352
DSE	hsa-miR-6502-3p	93.3156	NM_001322943
DSE	hsa-miR-4659b-3p	92.3242	NM_001322943
DSE	hsa-miR-4659a-3p	92.3242	NM_001322943
DSE	hsa-miR-3173-5p	91.5663	NM_001322944
DSE	hsa-miR-6799-3p	91.5663	NM_001322944
DSE	hsa-miR-3138	91.1023	NM_001322943
DSE	hsa-miR-4646-3p	90.8625	NM_001322944
DSE	hsa-miR-488-3p	90.8496	NM_013352
DSE	hsa-miR-6780a-3p	90.7381	NM_001322943
DSE	hsa-miR-576-5p	89.9965	NM_013352
DSE	hsa-miR-7155-5p	89.919	NM_013352
DSE	hsa-miR-8063	88.6831	NM_001322943
DSE	hsa-miR-6830-5p	88.4869	NM_013352
DSE	hsa-miR-7114-5p	87.9938	NM_001322943
DSE	hsa-miR-6730-5p	86.794	NM_013352
DSE	hsa-miR-664a-3p	85.5608	NM_001322943
DSE	hsa-miR-6881-5p	84.5443	NM_013352
DSE	hsa-miR-3160-5p	84.3787	NM_001322943
DSE	hsa-miR-3185	83.6428	NM_001322943
DSE	hsa-miR-4262	83.1872	NM_001322943
DSE	hsa-miR-3163	82.7739	NM_001322944
DSE	hsa-miR-8076	82.7496	NM_013352
DSE	hsa-miR-4649-3p	82.7259	NM_001322943
DSE	hsa-miR-4282	82.5523	NM_001322944
DSE	hsa-miR-1205	82.1063	NM_001322943
DSE	hsa-miR-10394-5p	82.1063	NM_001322943
DSE	hsa-miR-10395-3p	82.0877	NM_001322943
DSE	hsa-miR-646	81.9909	NM_001322943
DSE	hsa-miR-3680-3p	81.4704	NM_013352
DSE	hsa-miR-153-5p	81.3403	NM_001322943
DSE	hsa-miR-653-5p	80.9766	NM_001322943
DSE	hsa-miR-6512-5p	80.7031	NM_013352
DSE	hsa-miR-6090	80.4111	NM_001322943
DSE	hsa-miR-920	80.4111	NM_001322943
DSE	hsa-miR-6726-5p	80.4111	NM_001322943
DSE	hsa-miR-376a-3p	80.1633	NM_013352
DSE	hsa-miR-376b-3p	80.1633	NM_013352

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Motifs and transcription factors (TFs) regulating DSE

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DSE	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
DSE	transfac_pro__M01253	CNOT3 (directAnnotation).
DSE	transfac_pro__M02089	E2F3 (directAnnotation).
DSE	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DSE	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DSE	transfac_pro__M04916	TAF1 (directAnnotation).
DSE	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
DSE	transfac_pro__M12697	ZNF142 (directAnnotation).
DSE	transfac_pro__M06408	ZSCAN30 (directAnnotation).
DSE	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DSE	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DSE	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
DSE	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
DSE	jaspar__MA1721.1	ZNF93 (directAnnotation).
DSE	metacluster_151.2	ZNF23 (directAnnotation).
DSE	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DSE	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
DSE	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
DSE	transfac_pro__M01199	TRIM28 (directAnnotation).
DSE	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DSE	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
DSE	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
DSE	transfac_pro__M02913	SP140 (inferredBy_Orthology).
DSE	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
DSE	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
DSE	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
DSE	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DSE	cisbp__M00968	MTF2 (directAnnotation).
DSE	jaspar__MA0748.2	YY2 (directAnnotation).
DSE	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DSE	metacluster_7.13	ZFX (directAnnotation).
DSE	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
DSE	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DSE	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
DSE	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
DSE	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
DSE	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
DSE	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DSE	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
DSE	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DSE	transfac_pro__M07310	SP5 (directAnnotation).
DSE	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DSE	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
DSE	transfac_pro__M00938	E2F1 (directAnnotation).
DSE	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DSE	transfac_pro__M04893	TAF1 (directAnnotation).
DSE	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DSE	transfac_pro__M04817	ZBTB33 (directAnnotation).
DSE	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
DSE	metacluster_175.1	ZNF283 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."