Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DSCAM

Summary for DSCAM

Gene information	Gene symbol	DSCAM
	Ensembl ID	ENSG00000171587
	Entrez ID	1826
	Gene name	DS cell adhesion molecule
	Synonyms	CHD2-42\|CHD2-52
	Gene type	protein_coding
	UniProtAcc	O60469

Top

Dataset with differentially expressed gene: DSCAM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.353299	2.13e-25

Top

Expression of DSCAM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DSCAM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DSCAM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DSCAM	hsa-miR-219a-2-3p	98.6212	NM_001389
DSCAM	hsa-miR-6733-5p	96.5787	NM_001271534
DSCAM	hsa-miR-6739-5p	96.5787	NM_001271534
DSCAM	hsa-miR-3153	95.6466	NM_001271534
DSCAM	hsa-miR-196a-1-3p	94.6129	NM_001389
DSCAM	hsa-miR-1324	91.2875	NM_001389
DSCAM	hsa-miR-182-5p	90.8382	NM_001271534
DSCAM	hsa-miR-208b-5p	90.6696	NM_001271534
DSCAM	hsa-miR-1277-5p	90.3645	NM_001389
DSCAM	hsa-miR-208a-5p	89.7512	NM_001271534
DSCAM	hsa-miR-4753-3p	88.1699	NM_001389
DSCAM	hsa-miR-3674	85.4886	NM_001389
DSCAM	hsa-miR-4719	85.4536	NM_001271534
DSCAM	hsa-miR-6818-5p	85.0703	NM_001271534
DSCAM	hsa-miR-527	84.6651	NM_001271534
DSCAM	hsa-miR-518a-5p	84.6651	NM_001271534
DSCAM	hsa-miR-130a-5p	84.2573	NM_001389
DSCAM	hsa-miR-4668-5p	84.0206	NM_001271534
DSCAM	hsa-miR-3120-5p	83.6534	NM_001271534
DSCAM	hsa-miR-548m	83.0399	NM_001271534
DSCAM	hsa-miR-6809-3p	82.4306	NM_001389
DSCAM	hsa-miR-6870-3p	81.1995	NM_001389

Page: 1

Top

Motifs and transcription factors (TFs) regulating DSCAM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DSCAM	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
DSCAM	metacluster_122.17	IRF6 (directAnnotation).
DSCAM	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
DSCAM	transfac_pro__M02002	MECOM; RUNX1 (directAnnotation).
DSCAM	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
DSCAM	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."