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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DSC2

Summary for DSC2

Gene information	Gene symbol	DSC2
	Ensembl ID	ENSG00000134755
	Entrez ID	1824
	Gene name	desmocollin 2
	Synonyms	CDHF2\|DSC3
	Gene type	protein_coding
	UniProtAcc	Q02487

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Dataset with differentially expressed gene: DSC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.24883	3.22e-28
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.816445	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.843069	0.00e+00

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Expression of DSC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DSC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Endothelial cells	Malignant cells	GSE207422_Tor	post	resistant
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Malignant cells	Malignant cells	GSE207422_Tor	post	resistant
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Mono/Macro	Malignant cells	GSE207422_Tor	post	resistant
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Neutrophils	Malignant cells	GSE207422_Tor	post	resistant
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Fibroblasts	Malignant cells	GSE207422_Tor	post	sensitive
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Mono/Macro	Malignant cells	GSE207422_Tor	post	sensitive
DSC2	Malignant cells	CPI-SS06D13FCD3	DSC2_DSG2	DSC2	DSG2	False	Neutrophils	Malignant cells	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DSC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DSC2	hsa-miR-205-5p	96.7015	NM_004949
DSC2	hsa-miR-3128	92.674	NM_024422
DSC2	hsa-miR-520b-5p	91.0904	NM_024422
DSC2	hsa-miR-519a-2-5p	91.0904	NM_024422
DSC2	hsa-miR-4524a-3p	90.0532	NM_024422
DSC2	hsa-miR-5009-3p	89.6925	NM_004949
DSC2	hsa-miR-4282	89.2953	NM_004949
DSC2	hsa-miR-1323	89.003	NM_024422
DSC2	hsa-miR-92b-3p	88.8796	NM_024422
DSC2	hsa-miR-32-5p	88.8796	NM_024422
DSC2	hsa-miR-92a-3p	88.8796	NM_024422
DSC2	hsa-miR-5582-3p	88.0171	NM_024422
DSC2	hsa-miR-4778-3p	87.7948	NM_004949
DSC2	hsa-miR-3688-3p	87.5775	NM_024422
DSC2	hsa-miR-379-3p	86.769	NM_024422
DSC2	hsa-miR-411-3p	86.769	NM_024422
DSC2	hsa-miR-548o-3p	85.9722	NM_024422
DSC2	hsa-miR-4709-3p	85.5235	NM_024422
DSC2	hsa-miR-4672	85.4638	NM_004949
DSC2	hsa-miR-25-3p	85.4153	NM_024422
DSC2	hsa-miR-367-3p	85.4153	NM_024422
DSC2	hsa-miR-363-3p	85.4153	NM_024422
DSC2	hsa-miR-3121-3p	84.8231	NM_024422
DSC2	hsa-miR-4495	83.0483	NM_024422
DSC2	hsa-miR-548az-3p	82.4687	NM_024422
DSC2	hsa-miR-6774-5p	82.2201	NM_004949
DSC2	hsa-miR-635	82.2201	NM_004949
DSC2	hsa-miR-6507-5p	81.2017	NM_004949
DSC2	hsa-miR-4729	80.7102	NM_024422
DSC2	hsa-miR-548f-3p	80.2225	NM_024422
DSC2	hsa-miR-548a-3p	80.2225	NM_024422
DSC2	hsa-miR-548bc	80.2225	NM_024422
DSC2	hsa-miR-548e-3p	80.2225	NM_024422
DSC2	hsa-miR-548ar-3p	80.0712	NM_024422

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Motifs and transcription factors (TFs) regulating DSC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DSC2	metacluster_135.11	NR2C2 (directAnnotation).
DSC2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DSC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DSC2	metacluster_7.13	ZFX (directAnnotation).
DSC2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DSC2	cisbp__M00968	MTF2 (directAnnotation).
DSC2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DSC2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DSC2	cisbp__M00341	PAX6 (directAnnotation).
DSC2	metacluster_198.3	ZFP64 (directAnnotation).
DSC2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DSC2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DSC2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DSC2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DSC2	cisbp__M00788	ZFY (inferredBy_Orthology).
DSC2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DSC2	metacluster_175.1	ZNF283 (directAnnotation).
DSC2	hdpi__ZNF304	ZNF304 (directAnnotation).
DSC2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DSC2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DSC2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DSC2	transfac_pro__M01199	TRIM28 (directAnnotation).
DSC2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DSC2	metacluster_151.2	ZNF23 (directAnnotation).
DSC2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DSC2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DSC2	transfac_pro__M03806	ZBTB7C (directAnnotation).
DSC2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DSC2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DSC2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
DSC2	transfac_pro__M02089	E2F3 (directAnnotation).
DSC2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DSC2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DSC2	transfac_pro__M04817	ZBTB33 (directAnnotation).
DSC2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
DSC2	tfdimers__MD00483	ZBTB14 (directAnnotation).
DSC2	cisbp__M07938	E2F1 (directAnnotation).
DSC2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
DSC2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
DSC2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DSC2	jaspar__MA1122.1	TFDP1 (directAnnotation).
DSC2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DSC2	transfac_pro__M12697	ZNF142 (directAnnotation).
DSC2	transfac_pro__M06173	ZNF85 (directAnnotation).
DSC2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
DSC2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
DSC2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
DSC2	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
DSC2	tfdimers__MD00364	WT1 (directAnnotation).
DSC2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."