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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DPY19L4

Summary for DPY19L4

Gene information	Gene symbol	DPY19L4
	Ensembl ID	ENSG00000156162
	Entrez ID	286148
	Gene name	dpy-19 like 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DPY19L4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.266253	0.00e+00

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Expression of DPY19L4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DPY19L4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DPY19L4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DPY19L4	hsa-miR-195-3p	96.4383	NM_181787
DPY19L4	hsa-miR-16-2-3p	96.4383	NM_181787
DPY19L4	hsa-miR-1283	95.2352	NM_181787
DPY19L4	hsa-miR-4422	93.2878	NM_181787
DPY19L4	hsa-miR-4775	92.2214	NM_181787
DPY19L4	hsa-miR-6128	92.0338	NM_181787
DPY19L4	hsa-miR-5692a	91.4788	NM_181787
DPY19L4	hsa-miR-4699-5p	91.3742	NM_181787
DPY19L4	hsa-miR-7161-5p	91.0643	NM_181787
DPY19L4	hsa-miR-548u	90.1521	NM_181787
DPY19L4	hsa-miR-548t-5p	88.8972	NM_181787
DPY19L4	hsa-miR-548az-5p	88.8972	NM_181787
DPY19L4	hsa-miR-3613-3p	88.3767	NM_181787
DPY19L4	hsa-miR-6809-3p	87.628	NM_181787
DPY19L4	hsa-miR-3646	87.6227	NM_181787
DPY19L4	hsa-miR-891b	87.5481	NM_181787
DPY19L4	hsa-miR-6882-3p	86.0529	NM_181787
DPY19L4	hsa-miR-195-5p	85.9951	NM_181787
DPY19L4	hsa-miR-6838-5p	85.9951	NM_181787
DPY19L4	hsa-miR-497-5p	85.9951	NM_181787
DPY19L4	hsa-miR-15a-5p	85.9951	NM_181787
DPY19L4	hsa-miR-15b-5p	85.9951	NM_181787
DPY19L4	hsa-miR-16-5p	85.9951	NM_181787
DPY19L4	hsa-miR-424-5p	85.9951	NM_181787
DPY19L4	hsa-miR-4803	85.2198	NM_181787
DPY19L4	hsa-miR-545-5p	84.5764	NM_181787
DPY19L4	hsa-miR-128-3p	83.186	NM_181787
DPY19L4	hsa-miR-216a-3p	83.186	NM_181787
DPY19L4	hsa-miR-374a-5p	83.0764	NM_181787
DPY19L4	hsa-miR-302c-5p	82.891	NM_181787
DPY19L4	hsa-miR-4482-3p	82.4389	NM_181787
DPY19L4	hsa-miR-33a-3p	82.3205	NM_181787
DPY19L4	hsa-let-7g-3p	81.654	NM_181787
DPY19L4	hsa-let-7a-2-3p	81.654	NM_181787
DPY19L4	hsa-miR-4672	81.4383	NM_181787
DPY19L4	hsa-miR-450b-3p	81.0194	NM_181787
DPY19L4	hsa-miR-590-3p	80.7138	NM_181787
DPY19L4	hsa-miR-568	80.707	NM_181787
DPY19L4	hsa-miR-545-3p	80.6737	NM_181787
DPY19L4	hsa-miR-10522-5p	80.3109	NM_181787
DPY19L4	hsa-miR-3681-3p	80.1949	NM_181787

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Motifs and transcription factors (TFs) regulating DPY19L4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DPY19L4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
DPY19L4	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
DPY19L4	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
DPY19L4	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DPY19L4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DPY19L4	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
DPY19L4	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
DPY19L4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DPY19L4	transfac_pro__M00652	NRF1 (directAnnotation).
DPY19L4	hdpi__ETV4	ETV4 (directAnnotation).
DPY19L4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
DPY19L4	transfac_pro__M04866	HDAC2 (directAnnotation).
DPY19L4	jaspar__MA1122.1	TFDP1 (directAnnotation).
DPY19L4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
DPY19L4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
DPY19L4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
DPY19L4	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
DPY19L4	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."