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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DPP6

Summary for DPP6

Gene information	Gene symbol	DPP6
	Ensembl ID	ENSG00000130226
	Entrez ID	1804
	Gene name	dipeptidyl peptidase like 6
	Synonyms	DPL1\|DPPX
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DPP6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.254985	0.00e+00

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Expression of DPP6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DPP6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DPP6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DPP6	hsa-miR-300	94.7564	NM_001039350
DPP6	hsa-miR-381-3p	94.7564	NM_001039350
DPP6	hsa-miR-6513-3p	93.0621	NM_001290253
DPP6	hsa-miR-4500	91.9219	NM_001290253
DPP6	hsa-let-7a-5p	89.6146	NM_001290253
DPP6	hsa-let-7b-5p	89.6146	NM_001290253
DPP6	hsa-let-7c-5p	89.6146	NM_001290253
DPP6	hsa-let-7f-5p	89.6146	NM_001290253
DPP6	hsa-let-7i-5p	89.6146	NM_001290253
DPP6	hsa-let-7g-5p	89.6146	NM_001290253
DPP6	hsa-miR-98-5p	89.6146	NM_001290253
DPP6	hsa-let-7e-5p	89.6146	NM_001290253
DPP6	hsa-miR-668-3p	88.9344	NM_001290253
DPP6	hsa-miR-4458	88.4854	NM_001290253
DPP6	hsa-let-7d-5p	88.4854	NM_001290253
DPP6	hsa-miR-4645-3p	87.2619	NM_001039350
DPP6	hsa-miR-624-3p	84.9755	NM_001039350
DPP6	hsa-miR-218-5p	83.8862	NM_001039350
DPP6	hsa-miR-1972	83.6267	NM_001039350
DPP6	hsa-miR-4650-5p	83.6267	NM_001039350
DPP6	hsa-miR-138-1-3p	82.3844	NM_001290253
DPP6	hsa-miR-7113-5p	80.7424	NM_001290253
DPP6	hsa-miR-7162-5p	80.1021	NM_001039350
DPP6	hsa-miR-516a-3p	80.1021	NM_001039350
DPP6	hsa-miR-516b-3p	80.1021	NM_001039350

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Motifs and transcription factors (TFs) regulating DPP6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DPP6	hdpi__NFIX	NFIX (directAnnotation).
DPP6	transfac_pro__M03813	POU3F3 (directAnnotation).
DPP6	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
DPP6	hdpi__ZNF193	ZSCAN9 (directAnnotation).
DPP6	hdpi__FOXM1	FOXM1 (directAnnotation).
DPP6	transfac_pro__M06074	ZNF732 (directAnnotation).
DPP6	jaspar__MA1106.1	HIF1A (directAnnotation).
DPP6	transfac_pro__M02843	BBX (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."