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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: DPP4

Summary for DPP4

Gene informationGene symbol

DPP4

Ensembl ID

ENSG00000197635

Entrez ID

1803

Gene namedipeptidyl peptidase 4
SynonymsADCP2|CD26|DPPIV
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: DPP4

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-2.783691.01e-05

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Expression of DPP4 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to DPP4

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

DPP4

Aberration of the Drug's Therapeutic Target
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MicroRNAs (miRNA) regulating DPP4

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
DPP4hsa-miR-568098.4588NM_001935
DPP4hsa-miR-364696.6893NM_001935
DPP4hsa-miR-1251-3p94.9466NM_001935
DPP4hsa-miR-4766-5p93.877NM_001935
DPP4hsa-miR-873-3p92.3289NM_001935
DPP4hsa-miR-120090.5071NM_001935
DPP4hsa-miR-1252-3p90.3219NM_001935
DPP4hsa-miR-429188.3095NM_001935
DPP4hsa-miR-570-3p88.182NM_001935
DPP4hsa-miR-366887.8023NM_001935
DPP4hsa-miR-44887.6294NM_001935
DPP4hsa-miR-432487.5063NM_001935
DPP4hsa-miR-366286.9584NM_001935
DPP4hsa-miR-807585.8397NM_001935
DPP4hsa-miR-16-1-3p85.3355NM_001935
DPP4hsa-miR-361184.9315NM_001935
DPP4hsa-miR-574-5p84.8785NM_001935
DPP4hsa-miR-204-5p82.5842NM_001935
DPP4hsa-miR-211-5p82.5842NM_001935
DPP4hsa-miR-548e-5p80.8127NM_001935
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Motifs and transcription factors (TFs) regulating DPP4

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
DPP4"(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE"

DB07356

small molecule
DPP4"(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE"

DB06880

small molecule
DPP4"(1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFL

DB07072

small molecule
DPP4"(1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabi

DB07465

small molecule
DPP4"(2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE"

DB08051

small molecule
DPP4"(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-

DB07081

small molecule
DPP4"(2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYR

DB07482

small molecule
DPP4"(2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-

DB07193

small molecule
DPP4"(2s)-Pyrrolidin-2-Ylmethylamine"

DB03253

small molecule
DPP4"(2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A

DB07092

small molecule
DPP4"(2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-

DB07135

small molecule
DPP4"(2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopr

DB06994

small molecule
DPP4"(2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE"

DB07067

small molecule
DPP4"(2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-

DB06993

small molecule
DPP4"(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE"

DB07154

small molecule
DPP4"(3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE"

DB08164

small molecule
DPP4"(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine"

DB07015

small molecule
DPP4"(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE"

DB07851

small molecule
DPP4"(3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE"

DB08445

small molecule
DPP4"(3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE"

DB07666

small molecule
DPP4"(4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE"

DB07830

small molecule
DPP4"(7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine"

DB07021

small molecule
DPP4"(S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide"

DB04578

small molecule
DPP4"1-(1-phenylcyclopentyl)methylamine"

DB04577

small molecule
DPP4"1-biphenyl-2-ylmethanamine"

DB07412

small molecule
DPP4"1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE"

DB08024

small molecule
DPP4"2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE"

DB08588

small molecule
DPP4"2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)B

DB08743

small molecule
DPP4"2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One"

DB01884

small molecule
DPP4"4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide"

DB07181

small molecule
DPP4"4-Iodo-L-phenylalanine"

DB03660

small molecule
DPP4"4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one"

DB07271

small molecule
DPP4"4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE"

DB08672

small molecule
DPP4"5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine"

DB02004

small molecule
DPP4"6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHEN

DB08504

small molecule
DPP4"7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile"

DB07239

small molecule
DPP4"7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE"

DB08530

small molecule
DPP4"ABT-341"

DB08044

small molecule
DPP4"Alogliptin"

DB06203

small molecule
DPP4"AMG-222"

DB06011

small molecule
DPP4"Atorvastatin"

DB01076

small molecule
DPP4"Bisegliptin"

DB06127

small molecule
DPP4"Diisopropylphosphono Group"

DB04491

small molecule
DPP4"Dutogliptin"

DB11723

small molecule
DPP4"Gosogliptin"

DB08382

small molecule
DPP4"Linagliptin"

DB08882

small molecule
DPP4"METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO

DB07328

small molecule
DPP4"N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-MET

DB06939

small molecule
DPP4"N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE"

DB07779

small molecule
DPP4"N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benza

DB08429

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."

1Evaluation of the use of sitagliptin for insulin resistance in burn patients