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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DPH3

Summary for DPH3

Gene information	Gene symbol	DPH3
	Ensembl ID	ENSG00000154813
	Entrez ID	285381
	Gene name	diphthamide biosynthesis 3
	Synonyms	DELGIP\|DELGIP1\|DESR1\|DPH3A\|KTI11\|MGC20197\|ZCSL2
	Gene type	protein_coding
	UniProtAcc	Q96FX2

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Dataset with differentially expressed gene: DPH3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.533393	7.01e-45
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.5586	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.401896	3.57e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.266312	1.49e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.38892	4.05e-30
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.422339	0.00e+00

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Expression of DPH3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DPH3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DPH3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DPH3	hsa-miR-130a-5p	97.8868	NM_001047434
DPH3	hsa-miR-143-5p	96.5541	NM_001047434
DPH3	hsa-miR-4753-3p	95.6174	NM_001047434
DPH3	hsa-miR-3120-3p	94.7437	NM_001047434
DPH3	hsa-miR-545-3p	94.2258	NM_001047434
DPH3	hsa-miR-130b-5p	93.5022	NM_001047434
DPH3	hsa-miR-6857-3p	90.8722	NM_001047434
DPH3	hsa-miR-4773	90.6053	NM_001047434
DPH3	hsa-miR-2115-5p	90.0511	NM_001047434
DPH3	hsa-miR-590-3p	89.9531	NM_001047434
DPH3	hsa-miR-4328	89.729	NM_001047434
DPH3	hsa-miR-3622b-3p	87.3893	NM_001047434
DPH3	hsa-miR-3622a-3p	87.3893	NM_001047434
DPH3	hsa-miR-4500	86.4489	NM_001047434
DPH3	hsa-miR-7162-3p	84.997	NM_001047434
DPH3	hsa-miR-507	83.1911	NM_001047434
DPH3	hsa-miR-6809-3p	82.1467	NM_001047434
DPH3	hsa-miR-3128	81.9969	NM_001047434
DPH3	hsa-miR-7162-5p	81.8473	NM_001047434
DPH3	hsa-miR-610	81.6125	NM_001047434
DPH3	hsa-miR-6765-3p	80.386	NM_001047434
DPH3	hsa-let-7c-5p	80.3167	NM_001047434
DPH3	hsa-let-7i-5p	80.3167	NM_001047434
DPH3	hsa-miR-98-5p	80.3167	NM_001047434
DPH3	hsa-let-7b-5p	80.3167	NM_001047434
DPH3	hsa-let-7f-5p	80.3167	NM_001047434
DPH3	hsa-let-7e-5p	80.3167	NM_001047434
DPH3	hsa-let-7g-5p	80.3167	NM_001047434
DPH3	hsa-let-7a-5p	80.3167	NM_001047434

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Motifs and transcription factors (TFs) regulating DPH3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DPH3	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
DPH3	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
DPH3	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
DPH3	metacluster_81.7	CREB1 (directAnnotation).
DPH3	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
DPH3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
DPH3	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
DPH3	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
DPH3	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."