Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | CD8+ T cells | 0.303372 | 2.74e-08 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | cDCs | 0.928557 | 1.69e-09 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | NK cells | 0.482524 | 2.54e-14 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | Malignant cells | 0.328318 | 0.00e+00 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | CD4+ T cells | 0.326892 | 1.03e-37 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | -0.565614 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
DONSON | transfac_pro__M06763 | ZNF225 (directAnnotation). |
DONSON | metacluster_55.5 | ZNF541 (directAnnotation). |
DONSON | taipale_tf_pairs__CUX1_RFX5_RATCRATNNNNNNNNNRGYAAC_CAP_repr | CUX1; RFX5 (directAnnotation). |
DONSON | metacluster_44.13 | NKX3-1; NKX3-2 (directAnnotation). |
DONSON | metacluster_197.1 | E2F2; E2F3; E2F3; E2F4 (directAnnotation). |
DONSON | tfdimers__MD00190 | ARID3A; WT1 (directAnnotation). |
DONSON | taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP | CEBPD; ERF (directAnnotation). |
DONSON | transfac_pro__M05997 | ZFP64 (directAnnotation). |
DONSON | transfac_pro__M05769 | ZNF48 (inferredBy_Orthology). |
DONSON | taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP | CEBPD; FLI1 (directAnnotation). |
DONSON | tfdimers__MD00049 | MYB; OTX1; OTX2 (directAnnotation). |
DONSON | taipale_tf_pairs__FOXO1_ETV7_RWMAACAGGNNNNNNTTCCNN_CAP_repr | ETV7; FOXO1 (directAnnotation). |
DONSON | taipale_tf_pairs__TEAD4_CLOCK_NCACGTGNNNNNNCATWCC_CAP_repr | CLOCK; TEAD4 (directAnnotation). |
DONSON | transfac_pro__M05567 | OVOL1 (inferredBy_Orthology). |
DONSON | transfac_pro__M05449 | ZNF414 (inferredBy_Orthology). |
DONSON | transfac_pro__M06640 | ZNF251 (directAnnotation). |
DONSON | taipale_cyt_meth__VENTX_CGATTATCG_FL_repr | VENTX (directAnnotation). |
DONSON | metacluster_147.3 | MGA; MGA; TBX1; TBX15; TBX15; TBX18; TBX19; TBX20; TBX20; TBX20; TBX21; TBX22; ZNF18; ZNF18; ZNF18; ZNF18 (directAnnotation). MGA; TBX21 (inferredBy_Orthology). |
DONSON | transfac_pro__M01425 | HNF1B (directAnnotation). |
DONSON | tfdimers__MD00068 | HSF2; MYCN (directAnnotation). |
DONSON | transfac_pro__M06863 | ZNF789 (directAnnotation). |
DONSON | taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr | PITX1; TBX21 (directAnnotation). |
DONSON | transfac_pro__M05851 | ZNF768 (inferredBy_Orthology). |
DONSON | transfac_pro__M06223 | ZNF155 (directAnnotation). |
DONSON | taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr | HSF5 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |