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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DOCK5

Summary for DOCK5

Gene information	Gene symbol	DOCK5
	Ensembl ID	ENSG00000147459
	Entrez ID	80005
	Gene name	dedicator of cytokinesis 5
	Synonyms	FLJ21034
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DOCK5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.255516	1.01e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.465259	0.00e+00

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Expression of DOCK5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DOCK5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DOCK5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DOCK5	hsa-miR-5692a	98.0829	NM_024940
DOCK5	hsa-miR-3125	96.5917	NM_024940
DOCK5	hsa-miR-3916	96.5785	NM_024940
DOCK5	hsa-miR-6859-5p	96.2784	NM_024940
DOCK5	hsa-miR-4678	95.4822	NM_001322810
DOCK5	hsa-miR-4775	95.4721	NM_024940
DOCK5	hsa-miR-451b	95.3381	NM_024940
DOCK5	hsa-miR-4692	95.2895	NM_024940
DOCK5	hsa-miR-6770-5p	91.988	NM_024940
DOCK5	hsa-miR-6077	91.8963	NM_024940
DOCK5	hsa-miR-4514	91.7462	NM_024940
DOCK5	hsa-miR-3671	90.993	NM_024940
DOCK5	hsa-miR-7703	90.8164	NM_024940
DOCK5	hsa-miR-4311	90.1725	NM_024940
DOCK5	hsa-miR-4493	90.1017	NM_024940
DOCK5	hsa-miR-587	90.048	NM_024940
DOCK5	hsa-miR-330-3p	89.4427	NM_024940
DOCK5	hsa-miR-607	89.4113	NM_024940
DOCK5	hsa-miR-1236-3p	89.2375	NM_024940
DOCK5	hsa-miR-136-5p	89.0514	NM_024940
DOCK5	hsa-miR-32-3p	88.6765	NM_024940
DOCK5	hsa-miR-6758-5p	88.3601	NM_024940
DOCK5	hsa-miR-944	88.3107	NM_024940
DOCK5	hsa-miR-6856-5p	87.8284	NM_024940
DOCK5	hsa-miR-619-5p	87.8264	NM_024940
DOCK5	hsa-miR-6506-5p	87.8264	NM_024940
DOCK5	hsa-miR-575	87.3243	NM_024940
DOCK5	hsa-miR-4676-5p	87.3243	NM_024940
DOCK5	hsa-miR-4325	87.0358	NM_024940
DOCK5	hsa-miR-7-5p	86.8104	NM_024940
DOCK5	hsa-miR-12135	86.7689	NM_001322810
DOCK5	hsa-miR-380-3p	86.3525	NM_024940
DOCK5	hsa-miR-4515	85.5927	NM_024940
DOCK5	hsa-miR-331-5p	84.9752	NM_001322810
DOCK5	hsa-miR-6734-3p	84.8463	NM_024940
DOCK5	hsa-miR-501-5p	84.4406	NM_024940
DOCK5	hsa-miR-4503	84.4282	NM_001322810
DOCK5	hsa-miR-3978	84.3826	NM_024940
DOCK5	hsa-miR-4482-3p	84.1186	NM_024940
DOCK5	hsa-miR-153-5p	84.084	NM_024940
DOCK5	hsa-miR-4521	83.8158	NM_024940
DOCK5	hsa-miR-3202	83.5588	NM_024940
DOCK5	hsa-miR-92b-3p	83.5013	NM_024940
DOCK5	hsa-miR-92a-3p	83.5013	NM_024940
DOCK5	hsa-miR-32-5p	83.5013	NM_024940
DOCK5	hsa-miR-12123	82.7749	NM_024940
DOCK5	hsa-miR-6847-5p	82.4903	NM_024940
DOCK5	hsa-miR-624-5p	82.0888	NM_024940
DOCK5	hsa-miR-6881-5p	81.8891	NM_024940
DOCK5	hsa-miR-3674	81.155	NM_024940

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Motifs and transcription factors (TFs) regulating DOCK5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DOCK5	metacluster_135.11	NR2C2 (directAnnotation).
DOCK5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DOCK5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DOCK5	metacluster_7.13	ZFX (directAnnotation).
DOCK5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DOCK5	cisbp__M00968	MTF2 (directAnnotation).
DOCK5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DOCK5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DOCK5	cisbp__M00341	PAX6 (directAnnotation).
DOCK5	metacluster_198.3	ZFP64 (directAnnotation).
DOCK5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DOCK5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DOCK5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DOCK5	cisbp__M00788	ZFY (inferredBy_Orthology).
DOCK5	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DOCK5	metacluster_175.1	ZNF283 (directAnnotation).
DOCK5	hdpi__ZNF304	ZNF304 (directAnnotation).
DOCK5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DOCK5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DOCK5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DOCK5	transfac_pro__M01199	TRIM28 (directAnnotation).
DOCK5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DOCK5	metacluster_151.2	ZNF23 (directAnnotation).
DOCK5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DOCK5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DOCK5	transfac_pro__M03806	ZBTB7C (directAnnotation).
DOCK5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DOCK5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DOCK5	transfac_pro__M06639	ZNF559 (directAnnotation).
DOCK5	hdpi__GTF3C2	GTF3C2 (directAnnotation).
DOCK5	hdpi__FEZF2	FEZF2 (directAnnotation).
DOCK5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DOCK5	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DOCK5	hdpi__NRL	NRL (directAnnotation).
DOCK5	tfdimers__MD00483	ZBTB14 (directAnnotation).
DOCK5	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
DOCK5	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."