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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DOCK4

Summary for DOCK4

Gene information	Gene symbol	DOCK4
	Ensembl ID	ENSG00000128512
	Entrez ID	9732
	Gene name	dedicator of cytokinesis 4
	Synonyms	FLJ34238\|KIAA0716
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DOCK4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.57389	8.79e-04

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Expression of DOCK4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DOCK4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DOCK4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DOCK4	hsa-miR-302c-5p	99.5374	NM_014705
DOCK4	hsa-miR-4803	98.9489	NM_014705
DOCK4	hsa-miR-545-5p	97.913	NM_014705
DOCK4	hsa-miR-200a-3p	97.118	NM_014705
DOCK4	hsa-miR-141-3p	97.118	NM_014705
DOCK4	hsa-miR-3163	97.0668	NM_014705
DOCK4	hsa-miR-6890-3p	96.7002	NM_014705
DOCK4	hsa-miR-548e-5p	96.2735	NM_014705
DOCK4	hsa-miR-4775	95.9562	NM_014705
DOCK4	hsa-miR-5011-5p	95.8964	NM_014705
DOCK4	hsa-miR-181d-5p	95.8322	NM_014705
DOCK4	hsa-miR-181c-5p	95.8322	NM_014705
DOCK4	hsa-miR-181b-5p	95.8322	NM_014705
DOCK4	hsa-miR-181a-5p	95.8322	NM_014705
DOCK4	hsa-miR-3123	94.1168	NM_014705
DOCK4	hsa-miR-4262	94.0931	NM_014705
DOCK4	hsa-miR-520d-5p	93.4634	NM_014705
DOCK4	hsa-miR-524-5p	93.4634	NM_014705
DOCK4	hsa-let-7c-3p	93.0213	NM_014705
DOCK4	hsa-miR-4490	92.5435	NM_014705
DOCK4	hsa-miR-1297	92.3358	NM_014705
DOCK4	hsa-miR-548t-5p	92.3263	NM_014705
DOCK4	hsa-miR-6740-3p	91.5017	NM_014705
DOCK4	hsa-miR-590-3p	91.3921	NM_014705
DOCK4	hsa-miR-4789-3p	91.3555	NM_014705
DOCK4	hsa-miR-6768-5p	90.5847	NM_014705
DOCK4	hsa-miR-520e-5p	90.0666	NM_014705
DOCK4	hsa-miR-466	90.0483	NM_014705
DOCK4	hsa-miR-548az-5p	89.8513	NM_014705
DOCK4	hsa-miR-3682-5p	89.7321	NM_014705
DOCK4	hsa-miR-96-5p	89.7144	NM_014705
DOCK4	hsa-miR-182-5p	89.7144	NM_014705
DOCK4	hsa-miR-8485	89.6119	NM_014705
DOCK4	hsa-miR-4796-3p	88.8728	NM_014705
DOCK4	hsa-miR-10527-5p	88.6435	NM_014705
DOCK4	hsa-miR-26a-5p	87.6743	NM_014705
DOCK4	hsa-miR-26b-5p	87.6743	NM_014705
DOCK4	hsa-miR-20a-5p	87.5047	NM_014705
DOCK4	hsa-miR-106b-5p	87.5047	NM_014705
DOCK4	hsa-miR-1271-5p	87.1643	NM_014705
DOCK4	hsa-miR-12133	87.1643	NM_014705
DOCK4	hsa-miR-6835-3p	87.1066	NM_014705
DOCK4	hsa-miR-93-3p	86.9387	NM_014705
DOCK4	hsa-miR-190a-3p	86.9066	NM_014705
DOCK4	hsa-miR-519e-3p	86.6181	NM_014705
DOCK4	hsa-miR-515-3p	86.6181	NM_014705
DOCK4	hsa-miR-33b-3p	86.6181	NM_014705
DOCK4	hsa-miR-548l	86.284	NM_014705
DOCK4	hsa-miR-4297	86.2603	NM_014705
DOCK4	hsa-miR-17-5p	86.1615	NM_014705

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Motifs and transcription factors (TFs) regulating DOCK4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DOCK4	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
DOCK4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DOCK4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DOCK4	transfac_pro__M04617	ZBTB7A (directAnnotation).
DOCK4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DOCK4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DOCK4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DOCK4	transfac_pro__M07387	ZBTB7A (directAnnotation).
DOCK4	transfac_pro__M07436	WT1 (directAnnotation).
DOCK4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DOCK4	transfac_pro__M00716	ZBTB14 (directAnnotation).
DOCK4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DOCK4	hdpi__HIP2	UBE2K (directAnnotation).
DOCK4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DOCK4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DOCK4	transfac_pro__M03876	ZBTB33 (directAnnotation).
DOCK4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DOCK4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DOCK4	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DOCK4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DOCK4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."