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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJC22

Summary for DNAJC22

Gene information	Gene symbol	DNAJC22
	Ensembl ID	ENSG00000178401
	Entrez ID	79962
	Gene name	DnaJ heat shock protein family (Hsp40) member C22
	Synonyms	FLJ13236\|wus
	Gene type	protein_coding
	UniProtAcc	Q8N4W6

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Dataset with differentially expressed gene: DNAJC22

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.480756	3.16e-41

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Expression of DNAJC22 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAJC22

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAJC22

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJC22	hsa-miR-4436b-5p	95.3579	NM_024902
DNAJC22	hsa-miR-6756-5p	95.1621	NM_024902
DNAJC22	hsa-miR-6766-5p	93.1992	NM_024902
DNAJC22	hsa-miR-4775	91.5852	NM_024902
DNAJC22	hsa-miR-520f-5p	90.4541	NM_024902
DNAJC22	hsa-miR-7151-3p	90.2864	NM_024902
DNAJC22	hsa-miR-2117	87.9024	NM_024902
DNAJC22	hsa-miR-4445-5p	86.5377	NM_024902
DNAJC22	hsa-miR-3658	84.7984	NM_024902
DNAJC22	hsa-miR-466	84.0812	NM_024902
DNAJC22	hsa-miR-892c-5p	83.1138	NM_024902
DNAJC22	hsa-miR-2116-3p	82.7109	NM_024902
DNAJC22	hsa-miR-4694-3p	80.7046	NM_024902

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Motifs and transcription factors (TFs) regulating DNAJC22

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJC22	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."