Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJC11

Summary for DNAJC11

Gene information	Gene symbol	DNAJC11
	Ensembl ID	ENSG00000007923
	Entrez ID	55735
	Gene name	DnaJ heat shock protein family (Hsp40) member C11
	Synonyms	FLJ10737
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: DNAJC11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.278901	6.21e-19

Top

Expression of DNAJC11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DNAJC11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DNAJC11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJC11	hsa-miR-7156-5p	96.4456	NM_018198
DNAJC11	hsa-miR-4273	96.2092	NM_018198
DNAJC11	hsa-miR-5692c	94.1758	NM_018198
DNAJC11	hsa-miR-5692b	94.1758	NM_018198
DNAJC11	hsa-miR-3163	93.8684	NM_018198
DNAJC11	hsa-miR-6840-3p	93.7664	NM_018198
DNAJC11	hsa-miR-4731-5p	92.0771	NM_018198
DNAJC11	hsa-miR-4330	91.1416	NM_018198
DNAJC11	hsa-miR-6124	89.8473	NM_018198
DNAJC11	hsa-miR-3192-5p	85.6727	NM_018198
DNAJC11	hsa-miR-3189-3p	85.4515	NM_018198
DNAJC11	hsa-miR-548e-5p	85.0535	NM_018198
DNAJC11	hsa-miR-4677-5p	81.7623	NM_018198

Page: 1

Top

Motifs and transcription factors (TFs) regulating DNAJC11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJC11	transfac_pro__M04748	GABPA (directAnnotation).
DNAJC11	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
DNAJC11	transfac_pro__M00652	NRF1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."