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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJB4

Summary for DNAJB4

Gene information	Gene symbol	DNAJB4
	Ensembl ID	ENSG00000162616
	Entrez ID	11080
	Gene name	DnaJ heat shock protein family (Hsp40) member B4
	Synonyms	HLJ1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DNAJB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.387198	4.60e-23
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.304681	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.503947	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.397045	5.11e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.841449	5.42e-06

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Expression of DNAJB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAJB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAJB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJB4	hsa-miR-548k	98.9432	NM_001317099
DNAJB4	hsa-miR-548av-5p	98.9432	NM_001317099
DNAJB4	hsa-miR-8054	98.9432	NM_001317099
DNAJB4	hsa-miR-5011-5p	98.5868	NM_001317099
DNAJB4	hsa-miR-4666a-5p	97.7152	NM_001317099
DNAJB4	hsa-miR-3646	97.1068	NM_001317099
DNAJB4	hsa-miR-4477a	97.0333	NM_001317099
DNAJB4	hsa-miR-3185	97.0236	NM_001317103
DNAJB4	hsa-miR-195-5p	96.7487	NM_001317103
DNAJB4	hsa-miR-16-5p	96.7487	NM_001317103
DNAJB4	hsa-miR-15a-5p	96.7487	NM_001317103
DNAJB4	hsa-miR-15b-5p	96.7487	NM_001317103
DNAJB4	hsa-miR-190a-3p	96.5224	NM_001317099
DNAJB4	hsa-miR-424-5p	96.4431	NM_001317103
DNAJB4	hsa-miR-5683	96.3807	NM_001317099
DNAJB4	hsa-miR-6838-5p	96.2832	NM_001317103
DNAJB4	hsa-miR-497-5p	96.0566	NM_001317103
DNAJB4	hsa-miR-570-3p	95.374	NM_001317099
DNAJB4	hsa-miR-548c-3p	94.5897	NM_001317099
DNAJB4	hsa-miR-10527-5p	93.7213	NM_001317103
DNAJB4	hsa-miR-559	93.066	NM_001317099
DNAJB4	hsa-miR-5680	92.8053	NM_001317099
DNAJB4	hsa-miR-876-5p	92.6835	NM_001317099
DNAJB4	hsa-miR-12136	92.6264	NM_001317099
DNAJB4	hsa-miR-3167	92.2208	NM_001317099
DNAJB4	hsa-miR-1277-5p	91.9989	NM_001317103
DNAJB4	hsa-miR-548z	91.5722	NM_001317103
DNAJB4	hsa-miR-548ac	91.5722	NM_001317103
DNAJB4	hsa-miR-548h-3p	91.5722	NM_001317103
DNAJB4	hsa-miR-3059-5p	91.327	NM_001317099
DNAJB4	hsa-miR-548ad-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ap-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ar-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548w	91.2422	NM_001317099
DNAJB4	hsa-miR-548h-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548c-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548bb-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548b-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548y	91.2422	NM_001317099
DNAJB4	hsa-miR-548j-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ae-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548as-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548aq-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548o-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ay-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ab	91.2422	NM_001317099
DNAJB4	hsa-miR-548au-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548d-5p	91.2422	NM_001317099
DNAJB4	hsa-miR-548ak	91.2422	NM_001317099
DNAJB4	hsa-miR-548i	91.2422	NM_001317099

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Motifs and transcription factors (TFs) regulating DNAJB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJB4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DNAJB4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DNAJB4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DNAJB4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DNAJB4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DNAJB4	metacluster_151.2	ZNF23 (directAnnotation).
DNAJB4	transfac_pro__M00514	ATF4 (directAnnotation).
DNAJB4	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
DNAJB4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DNAJB4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
DNAJB4	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
DNAJB4	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
DNAJB4	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
DNAJB4	cisbp__M00809	PRDM11 (inferredBy_Orthology).
DNAJB4	hdpi__NRL	NRL (directAnnotation).
DNAJB4	transfac_pro__M02898	SMAD3 (directAnnotation).
DNAJB4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
DNAJB4	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
DNAJB4	transfac_pro__M01861	ATF1 (directAnnotation).
DNAJB4	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
DNAJB4	metacluster_111.5	E4F1; E4F1 (directAnnotation).
DNAJB4	hdpi__TIMELESS	TIMELESS (directAnnotation).
DNAJB4	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
DNAJB4	transfac_pro__M01864	ATF4 (directAnnotation).
DNAJB4	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
DNAJB4	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
DNAJB4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
DNAJB4	transfac_pro__M06208	ZNF460 (directAnnotation).
DNAJB4	transfac_public__M00114	CREB1 (directAnnotation).
DNAJB4	transfac_pro__M06035	ZNF749 (directAnnotation).
DNAJB4	transfac_pro__M06545	ZNF485 (directAnnotation).
DNAJB4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DNAJB4	jaspar__MA1650.1	ZBTB14 (directAnnotation).
DNAJB4	transfac_pro__M04817	ZBTB33 (directAnnotation).
DNAJB4	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
DNAJB4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
DNAJB4	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
DNAJB4	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
DNAJB4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
DNAJB4	hdpi__RARA	RARA (directAnnotation).
DNAJB4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
DNAJB4	transfac_pro__M04893	TAF1 (directAnnotation).
DNAJB4	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
DNAJB4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
DNAJB4	hdpi__HTATIP2	HTATIP2 (directAnnotation).
DNAJB4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
DNAJB4	hdpi__OTUD4	OTUD4 (directAnnotation).
DNAJB4	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."