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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJA2

Summary for DNAJA2

Gene information	Gene symbol	DNAJA2
	Ensembl ID	ENSG00000069345
	Entrez ID	10294
	Gene name	DnaJ heat shock protein family (Hsp40) member A2
	Synonyms	CPR3\|DNAJ\|DNJ3\|HIRIP4
	Gene type	protein_coding
	UniProtAcc	O60884

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Dataset with differentially expressed gene: DNAJA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.278771	1.74e-11
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.382633	1.11e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.453362	2.01e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.271754	2.85e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.416835	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.326472	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.288943	0.00e+00

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Expression of DNAJA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAJA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAJA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJA2	hsa-miR-19b-3p	96.6305	NM_005880
DNAJA2	hsa-miR-19a-3p	96.6305	NM_005880
DNAJA2	hsa-let-7c-3p	95.9717	NM_005880
DNAJA2	hsa-miR-513b-5p	94.6428	NM_005880
DNAJA2	hsa-miR-190b-3p	94.229	NM_005880
DNAJA2	hsa-miR-4698	93.8378	NM_005880
DNAJA2	hsa-miR-548c-3p	93.3155	NM_005880
DNAJA2	hsa-miR-5000-3p	92.7838	NM_005880
DNAJA2	hsa-miR-5581-3p	92.1467	NM_005880
DNAJA2	hsa-miR-1914-5p	91.0688	NM_005880
DNAJA2	hsa-miR-4438	91.0334	NM_005880
DNAJA2	hsa-miR-4436a	90.9542	NM_005880
DNAJA2	hsa-miR-646	90.8865	NM_005880
DNAJA2	hsa-miR-4789-5p	90.6116	NM_005880
DNAJA2	hsa-miR-1323	90.4236	NM_005880
DNAJA2	hsa-miR-548o-3p	90.4236	NM_005880
DNAJA2	hsa-miR-4524b-5p	90.1981	NM_005880
DNAJA2	hsa-miR-4524a-5p	90.1981	NM_005880
DNAJA2	hsa-miR-6839-5p	90.0219	NM_005880
DNAJA2	hsa-miR-4742-5p	89.9294	NM_005880
DNAJA2	hsa-miR-4495	89.876	NM_005880
DNAJA2	hsa-miR-494-3p	89.5394	NM_005880
DNAJA2	hsa-miR-6796-5p	88.3265	NM_005880
DNAJA2	hsa-miR-4491	88.0445	NM_005880
DNAJA2	hsa-miR-4657	88.0445	NM_005880
DNAJA2	hsa-miR-6868-3p	87.4562	NM_005880
DNAJA2	hsa-miR-4501	87.3192	NM_005880
DNAJA2	hsa-miR-670-3p	87.2623	NM_005880
DNAJA2	hsa-miR-625-3p	86.6104	NM_005880
DNAJA2	hsa-miR-1972	86.1763	NM_005880
DNAJA2	hsa-miR-4426	85.9429	NM_005880
DNAJA2	hsa-miR-4500	85.8326	NM_005880
DNAJA2	hsa-miR-3664-5p	85.662	NM_005880
DNAJA2	hsa-miR-378j	85.5752	NM_005880
DNAJA2	hsa-miR-491-5p	85.4982	NM_005880
DNAJA2	hsa-miR-5681a	85.0129	NM_005880
DNAJA2	hsa-let-7f-5p	84.6683	NM_005880
DNAJA2	hsa-miR-4458	84.6683	NM_005880
DNAJA2	hsa-let-7g-5p	84.6683	NM_005880
DNAJA2	hsa-let-7c-5p	84.6683	NM_005880
DNAJA2	hsa-miR-98-5p	84.6683	NM_005880
DNAJA2	hsa-let-7e-5p	84.6683	NM_005880
DNAJA2	hsa-let-7i-5p	84.6683	NM_005880
DNAJA2	hsa-let-7a-5p	84.6683	NM_005880
DNAJA2	hsa-let-7d-5p	84.6683	NM_005880
DNAJA2	hsa-let-7b-5p	84.6683	NM_005880
DNAJA2	hsa-miR-4654	84.6495	NM_005880
DNAJA2	hsa-miR-4802-5p	84.397	NM_005880
DNAJA2	hsa-miR-1843	84.397	NM_005880
DNAJA2	hsa-miR-6780b-5p	83.9722	NM_005880

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Motifs and transcription factors (TFs) regulating DNAJA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJA2	metacluster_7.13	ZFX (directAnnotation).
DNAJA2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DNAJA2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
DNAJA2	jaspar__MA1483.2	ELF2 (directAnnotation).
DNAJA2	metacluster_151.2	ZNF23 (directAnnotation).
DNAJA2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DNAJA2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
DNAJA2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DNAJA2	transfac_pro__M05628	ZNF735 (directAnnotation).
DNAJA2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DNAJA2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
DNAJA2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
DNAJA2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
DNAJA2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
DNAJA2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
DNAJA2	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
DNAJA2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
DNAJA2	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
DNAJA2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
DNAJA2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
DNAJA2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
DNAJA2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
DNAJA2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DNAJA2	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
DNAJA2	metacluster_81.7	CREB1 (directAnnotation).
DNAJA2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
DNAJA2	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
DNAJA2	hdpi__FLI1	FLI1 (directAnnotation).
DNAJA2	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
DNAJA2	transfac_public__M00041	ATF2; JUN (directAnnotation).
DNAJA2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."