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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAH14

Summary for DNAH14

Gene information	Gene symbol	DNAH14
	Ensembl ID	ENSG00000185842
	Entrez ID	127602
	Gene name	dynein axonemal heavy chain 14
	Synonyms	C1orf67\|DKFZp781B1548\|Dnahc14\|HL-18\|HL18\|MGC27277
	Gene type	protein_coding
	UniProtAcc	Q0VDD8

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Dataset with differentially expressed gene: DNAH14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.354457	5.02e-24
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.307577	0.00e+00

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Expression of DNAH14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAH14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAH14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAH14	hsa-miR-548p	96.1637	NM_001145154
DNAH14	hsa-miR-4795-3p	91.8336	NM_144989
DNAH14	hsa-miR-7-2-3p	91.5621	NM_001145154
DNAH14	hsa-miR-7-1-3p	91.5621	NM_001145154
DNAH14	hsa-miR-627-3p	91.1637	NM_144989
DNAH14	hsa-miR-7-5p	90.758	NM_001145154
DNAH14	hsa-miR-302c-5p	89.5547	NM_001145154
DNAH14	hsa-miR-4680-3p	85.9791	NM_001145154
DNAH14	hsa-miR-3942-3p	84.7478	NM_001145154
DNAH14	hsa-miR-6837-3p	84.1126	NM_144989
DNAH14	hsa-miR-4684-5p	83.7494	NM_144989
DNAH14	hsa-miR-590-3p	82.599	NM_001145154
DNAH14	hsa-miR-216b-5p	80.7075	NM_144989
DNAH14	hsa-miR-3688-5p	80.2962	NM_001145154

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Motifs and transcription factors (TFs) regulating DNAH14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAH14	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
DNAH14	transfac_pro__M04918	EGR1 (directAnnotation).
DNAH14	metacluster_7.13	ZFX (directAnnotation).
DNAH14	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DNAH14	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
DNAH14	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DNAH14	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DNAH14	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DNAH14	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DNAH14	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DNAH14	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."