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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DMTF1

Summary for DMTF1

Gene information	Gene symbol	DMTF1
	Ensembl ID	ENSG00000135164
	Entrez ID	9988
	Gene name	cyclin D binding myb like transcription factor 1
	Synonyms	DMP1\|DMTF\|hDMP1\|MRUL
	Gene type	protein_coding
	UniProtAcc	Q9Y222

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Dataset with differentially expressed gene: DMTF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.882507	2.03e-05

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Expression of DMTF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DMTF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DMTF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DMTF1	hsa-miR-211-5p	95.0918	NM_001142327
DMTF1	hsa-miR-204-5p	95.0918	NM_001142327
DMTF1	hsa-miR-6832-3p	94.2372	NM_021145
DMTF1	hsa-miR-3611	92.4752	NM_001142327
DMTF1	hsa-miR-627-3p	92.3255	NM_021145
DMTF1	hsa-miR-6844	92.17	NM_001142327
DMTF1	hsa-miR-1202	91.776	NM_021145
DMTF1	hsa-miR-6073	91.4259	NM_021145
DMTF1	hsa-miR-548n	91.14	NM_001142327
DMTF1	hsa-miR-4652-3p	89.7573	NM_001142327
DMTF1	hsa-miR-3972	89.6018	NM_021145
DMTF1	hsa-miR-20b-3p	89.2887	NM_021145
DMTF1	hsa-miR-4524a-5p	88.4026	NM_021145
DMTF1	hsa-miR-4524b-5p	88.4026	NM_021145
DMTF1	hsa-miR-5003-3p	87.9692	NM_021145
DMTF1	hsa-miR-15a-5p	87.5705	NM_021145
DMTF1	hsa-miR-16-5p	87.5705	NM_021145
DMTF1	hsa-miR-15b-5p	87.5705	NM_021145
DMTF1	hsa-miR-195-5p	87.5705	NM_021145
DMTF1	hsa-miR-1245b-3p	87.0964	NM_021145
DMTF1	hsa-let-7b-3p	86.4031	NM_001142327
DMTF1	hsa-let-7f-1-3p	86.4031	NM_001142327
DMTF1	hsa-let-7a-3p	86.4031	NM_001142327
DMTF1	hsa-miR-98-3p	86.4031	NM_001142327
DMTF1	hsa-miR-3194-5p	86.2219	NM_021145
DMTF1	hsa-miR-8088	86.1311	NM_001142327
DMTF1	hsa-miR-520h	85.9923	NM_021145
DMTF1	hsa-miR-520g-3p	85.9923	NM_021145
DMTF1	hsa-miR-548g-3p	85.0765	NM_001142327
DMTF1	hsa-miR-4709-3p	84.8137	NM_001142327
DMTF1	hsa-miR-548av-3p	84.4678	NM_001142327
DMTF1	hsa-miR-5692a	84.3426	NM_001142327
DMTF1	hsa-miR-6885-3p	83.3119	NM_001142327
DMTF1	hsa-miR-3938	83.2121	NM_001142327
DMTF1	hsa-miR-4635	82.7425	NM_001142327
DMTF1	hsa-miR-5006-3p	82.6919	NM_001142327
DMTF1	hsa-miR-4755-5p	82.6919	NM_001142327
DMTF1	hsa-miR-424-5p	82.315	NM_021145
DMTF1	hsa-miR-497-5p	82.315	NM_021145
DMTF1	hsa-miR-6838-5p	82.315	NM_021145
DMTF1	hsa-miR-4666a-3p	81.3721	NM_001142327
DMTF1	hsa-miR-520d-3p	80.4442	NM_021145
DMTF1	hsa-miR-520a-3p	80.4442	NM_021145
DMTF1	hsa-miR-302e	80.4442	NM_021145
DMTF1	hsa-miR-642b-5p	80.1985	NM_021145

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Motifs and transcription factors (TFs) regulating DMTF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DMTF1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
DMTF1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DMTF1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DMTF1	transfac_pro__M04617	ZBTB7A (directAnnotation).
DMTF1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DMTF1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
DMTF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DMTF1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DMTF1	transfac_pro__M07387	ZBTB7A (directAnnotation).
DMTF1	transfac_pro__M07436	WT1 (directAnnotation).
DMTF1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DMTF1	transfac_pro__M00716	ZBTB14 (directAnnotation).
DMTF1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DMTF1	hdpi__HIP2	UBE2K (directAnnotation).
DMTF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DMTF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DMTF1	transfac_pro__M04893	TAF1 (directAnnotation).
DMTF1	transfac_pro__M03876	ZBTB33 (directAnnotation).
DMTF1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DMTF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DMTF1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DMTF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DMTF1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."