Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DMRT3

Summary for DMRT3

Gene information	Gene symbol	DMRT3
	Ensembl ID	ENSG00000064218
	Entrez ID	58524
	Gene name	doublesex and mab-3 related transcription factor 3
	Synonyms	DMRTA3
	Gene type	protein_coding
	UniProtAcc	Q9NQL9

Top

Dataset with differentially expressed gene: DMRT3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.3815	1.49e-06

Top

Expression of DMRT3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DMRT3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DMRT3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DMRT3	hsa-miR-137-3p	95.3666	NM_021240
DMRT3	hsa-miR-26b-5p	95.1021	NM_021240
DMRT3	hsa-miR-26a-5p	95.1021	NM_021240
DMRT3	hsa-miR-1297	94.8827	NM_021240
DMRT3	hsa-miR-3143	93.7585	NM_021240
DMRT3	hsa-miR-4465	93.183	NM_021240
DMRT3	hsa-miR-593-3p	92.291	NM_021240
DMRT3	hsa-miR-222-3p	91.506	NM_021240
DMRT3	hsa-miR-221-3p	91.506	NM_021240
DMRT3	hsa-miR-130a-5p	91.3011	NM_021240
DMRT3	hsa-miR-6873-3p	88.8209	NM_021240
DMRT3	hsa-miR-544b	87.9727	NM_021240
DMRT3	hsa-miR-543	87.1867	NM_021240
DMRT3	hsa-miR-122b-5p	85.9584	NM_021240
DMRT3	hsa-miR-3157-5p	85.8363	NM_021240
DMRT3	hsa-miR-383-3p	85.7188	NM_021240
DMRT3	hsa-miR-4753-3p	85.2477	NM_021240
DMRT3	hsa-miR-4307	84.7331	NM_021240
DMRT3	hsa-miR-581	84.4421	NM_021240
DMRT3	hsa-miR-548v	83.6588	NM_021240
DMRT3	hsa-miR-187-5p	83.6588	NM_021240
DMRT3	hsa-miR-146a-3p	82.0238	NM_021240
DMRT3	hsa-miR-4761-3p	81.1452	NM_021240
DMRT3	hsa-miR-6818-3p	80.416	NM_021240
DMRT3	hsa-miR-26a-1-3p	80.4063	NM_021240
DMRT3	hsa-miR-26a-2-3p	80.4063	NM_021240
DMRT3	hsa-miR-5002-5p	80.0386	NM_021240

Page: 1

Top

Motifs and transcription factors (TFs) regulating DMRT3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."