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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DLX5

Summary for DLX5

Gene information	Gene symbol	DLX5
	Ensembl ID	ENSG00000105880
	Entrez ID	1749
	Gene name	distal-less homeobox 5
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P56178

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Dataset with differentially expressed gene: DLX5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.818131	0.00e+00

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Expression of DLX5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DLX5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DLX5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DLX5	hsa-miR-4666a-5p	96.7247	NM_005221
DLX5	hsa-miR-593-5p	95.0469	NM_005221
DLX5	hsa-miR-9851-3p	95.0469	NM_005221
DLX5	hsa-miR-5588-3p	94.9638	NM_005221
DLX5	hsa-miR-12136	94.1628	NM_005221
DLX5	hsa-miR-203a-3p	91.7896	NM_005221
DLX5	hsa-miR-590-3p	90.6149	NM_005221
DLX5	hsa-miR-4775	90.3133	NM_005221
DLX5	hsa-miR-4643	89.8773	NM_005221
DLX5	hsa-miR-5692a	88.9387	NM_005221
DLX5	hsa-let-7i-3p	88.3303	NM_005221
DLX5	hsa-miR-1264	87.309	NM_005221
DLX5	hsa-miR-3613-3p	87.1269	NM_005221
DLX5	hsa-miR-506-3p	86.8324	NM_005221
DLX5	hsa-miR-124-3p	86.8324	NM_005221
DLX5	hsa-miR-466	86.7122	NM_005221
DLX5	hsa-miR-942-3p	86.5713	NM_005221
DLX5	hsa-miR-10393-5p	83.2569	NM_005221
DLX5	hsa-miR-5586-5p	82.8684	NM_005221
DLX5	hsa-miR-2114-5p	81.8215	NM_005221
DLX5	hsa-miR-4452	80.6515	NM_005221
DLX5	hsa-miR-548aw	80.1133	NM_005221

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Motifs and transcription factors (TFs) regulating DLX5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DLX5	transfac_pro__M04848	TAF1 (directAnnotation).
DLX5	transfac_pro__M05670	ZNF37A (directAnnotation).
DLX5	stark__RCGCMATTW	YY1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."