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![]() | Expression of this gene in the resistant group across all datasets and cell types |
![]() | Significant ligand-receptor pairs related to this gene (This gene does not contain this module) |
![]() | Known drug resistance mechanisms of this gene (This gene does not contain this module) |
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![]() | Acts as a transcription factor (This gene does not contain this module) |
![]() | Acts as a drug target< (This gene does not contain this module) |
Gene: DLX4 |
Summary for DLX4 |
Gene information | Gene symbol | DLX4 | Ensembl ID | ENSG00000108813 |
Entrez ID | 1748 | |
Gene name | distal-less homeobox 4 | |
Synonyms | BP1|DLX7|DLX8|DLX9 | |
Gene type | protein_coding | |
UniProtAcc | Q92988 |
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Dataset with differentially expressed gene: DLX4 |
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Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | 1.8961 | 4.64e-11 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | 0.254152 | 0.00e+00 |
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Expression of DLX4 in the resistant group across all datasets and cell types |
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Significant ligand-receptor pairs related to DLX4 |
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Known drug resistance mechanisms of this gene |
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MicroRNAs (miRNA) regulating DLX4 |
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Gene symbol | miRNA | Score | GeneBank accession |
DLX4 | hsa-miR-524-5p | 86.0932 | NM_001934 |
DLX4 | hsa-miR-520d-5p | 86.0932 | NM_001934 |
DLX4 | hsa-miR-4279 | 85.5848 | NM_001934 |
DLX4 | hsa-miR-1910-5p | 81.178 | NM_001934 |
DLX4 | hsa-miR-939-3p | 81.1408 | NM_001934 |
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Motifs and transcription factors (TFs) regulating DLX4 |
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Gene symbol | motif | TF_highConf |
DLX4 | taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr | ELF1; MEIS1 (directAnnotation). |
DLX4 | cisbp__M02645 | ETS1 (directAnnotation). |
DLX4 | transfac_pro__M06156 | ZNF75D (directAnnotation). |
DLX4 | swissregulon__hs__ETV6 | ETV6 (directAnnotation). |
DLX4 | cisbp__M00808 | MYPOP (inferredBy_Orthology). |
DLX4 | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
DLX4 | metacluster_198.7 | AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation). |
DLX4 | taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr | GCM1; SPDEF (directAnnotation). |
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Acts as a transcription factor |
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Acts as a drug target |
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1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |