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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DLG5

Summary for DLG5

Gene information	Gene symbol	DLG5
	Ensembl ID	ENSG00000274429
	Entrez ID	9231
	Gene name	discs large MAGUK scaffold protein 5
	Synonyms	KIAA0583\|P-dlg
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DLG5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.334038	1.50e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.484094	3.80e-40
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.383085	3.51e-21

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Expression of DLG5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DLG5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DLG5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DLG5	hsa-miR-19b-3p	99.2298	NM_004747
DLG5	hsa-miR-19a-3p	99.2298	NM_004747
DLG5	hsa-miR-520d-5p	99.0462	NM_004747
DLG5	hsa-miR-524-5p	99.0462	NM_004747
DLG5	hsa-miR-3662	98.9786	NM_004747
DLG5	hsa-miR-3646	98.712	NM_004747
DLG5	hsa-miR-6759-3p	96.9351	NM_004747
DLG5	hsa-miR-6507-5p	96.3579	NM_004747
DLG5	hsa-miR-6832-3p	95.8895	NM_004747
DLG5	hsa-miR-204-5p	95.4426	NM_004747
DLG5	hsa-miR-211-5p	95.4426	NM_004747
DLG5	hsa-miR-30b-5p	94.7683	NM_004747
DLG5	hsa-miR-30a-5p	94.7683	NM_004747
DLG5	hsa-miR-30c-5p	94.7683	NM_004747
DLG5	hsa-miR-30d-5p	94.7683	NM_004747
DLG5	hsa-miR-30e-5p	94.7683	NM_004747
DLG5	hsa-miR-1297	94.7442	NM_004747
DLG5	hsa-miR-6866-3p	94.492	NM_004747
DLG5	hsa-miR-188-5p	94.492	NM_004747
DLG5	hsa-miR-6508-5p	94.3447	NM_004747
DLG5	hsa-miR-26a-5p	94.0202	NM_004747
DLG5	hsa-miR-26b-5p	94.0202	NM_004747
DLG5	hsa-miR-4303	93.9912	NM_004747
DLG5	hsa-miR-4295	93.784	NM_004747
DLG5	hsa-miR-130a-3p	93.784	NM_004747
DLG5	hsa-miR-130b-3p	93.784	NM_004747
DLG5	hsa-miR-301a-3p	93.784	NM_004747
DLG5	hsa-miR-3666	93.784	NM_004747
DLG5	hsa-miR-301b-3p	93.784	NM_004747
DLG5	hsa-miR-454-3p	93.784	NM_004747
DLG5	hsa-miR-3914	93.7553	NM_004747
DLG5	hsa-miR-1258	93.6734	NM_004747
DLG5	hsa-miR-4465	93.5864	NM_004747
DLG5	hsa-miR-8067	93.3599	NM_004747
DLG5	hsa-miR-16-1-3p	92.6215	NM_004747
DLG5	hsa-miR-203a-3p	92.5706	NM_004747
DLG5	hsa-miR-5580-5p	92.4001	NM_004747
DLG5	hsa-miR-3663-3p	91.5458	NM_004747
DLG5	hsa-miR-3613-5p	91.3624	NM_004747
DLG5	hsa-miR-5697	91.0731	NM_004747
DLG5	hsa-miR-519a-3p	88.6714	NM_004747
DLG5	hsa-miR-519c-3p	88.6714	NM_004747
DLG5	hsa-miR-519b-3p	88.6714	NM_004747
DLG5	hsa-miR-101-3p	88.2589	NM_004747
DLG5	hsa-miR-3973	87.9776	NM_004747
DLG5	hsa-miR-7106-5p	87.7645	NM_004747
DLG5	hsa-miR-144-3p	86.4386	NM_004747
DLG5	hsa-miR-6734-3p	86.3339	NM_004747
DLG5	hsa-miR-7152-3p	83.9479	NM_004747
DLG5	hsa-miR-103a-3p	83.8834	NM_004747

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Motifs and transcription factors (TFs) regulating DLG5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DLG5	transfac_pro__M06602	ZNF669 (directAnnotation).
DLG5	jaspar__MA0079.5	SP1 (directAnnotation).
DLG5	transfac_pro__M01253	CNOT3 (directAnnotation).
DLG5	transfac_pro__M04817	ZBTB33 (directAnnotation).
DLG5	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."