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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: DLAT

Summary for DLAT

Gene information	Gene symbol	DLAT
	Ensembl ID	ENSG00000150768
	Entrez ID	1737
	Gene name	dihydrolipoamide S-acetyltransferase
	Synonyms	DLTA\|E2\|PDC-E2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DLAT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.630007	0.00e+00

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Expression of DLAT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DLAT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DLAT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DLAT	hsa-miR-153-5p	96.0432	NM_001931
DLAT	hsa-miR-5692a	94.5644	NM_001931
DLAT	hsa-miR-513c-3p	94.0484	NM_001931
DLAT	hsa-miR-513a-3p	94.0484	NM_001931
DLAT	hsa-miR-3606-3p	92.6567	NM_001931
DLAT	hsa-miR-548c-3p	92.5358	NM_001931
DLAT	hsa-miR-4768-5p	91.0266	NM_001931
DLAT	hsa-miR-10b-3p	90.8393	NM_001931
DLAT	hsa-miR-6833-3p	90.7821	NM_001931
DLAT	hsa-miR-365a-3p	89.9505	NM_001931
DLAT	hsa-miR-365b-3p	89.9505	NM_001931
DLAT	hsa-miR-3941	89.5629	NM_001931
DLAT	hsa-miR-4775	89.5082	NM_001931
DLAT	hsa-miR-376b-3p	89.2074	NM_001931
DLAT	hsa-miR-376a-3p	89.2074	NM_001931
DLAT	hsa-miR-6128	88.8644	NM_001931
DLAT	hsa-miR-6513-5p	88.6	NM_001931
DLAT	hsa-miR-3911	87.7139	NM_001931
DLAT	hsa-miR-582-3p	87.6783	NM_001931
DLAT	hsa-miR-6772-5p	87.3009	NM_001931
DLAT	hsa-miR-33a-3p	86.2707	NM_001931
DLAT	hsa-miR-4641	85.344	NM_001931
DLAT	hsa-miR-1271-5p	85.3409	NM_001931
DLAT	hsa-miR-1279	84.92	NM_001931
DLAT	hsa-miR-96-5p	84.4067	NM_001931
DLAT	hsa-miR-12133	83.2466	NM_001931
DLAT	hsa-miR-4477a	82.475	NM_001931
DLAT	hsa-miR-6750-5p	82.396	NM_001931
DLAT	hsa-miR-6822-5p	82.396	NM_001931
DLAT	hsa-miR-6734-3p	81.1412	NM_001931
DLAT	hsa-miR-2682-5p	81.0233	NM_001931
DLAT	hsa-miR-3920	80.4373	NM_001931
DLAT	hsa-miR-935	80.3572	NM_001931
DLAT	hsa-miR-466	80.2133	NM_001931

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Motifs and transcription factors (TFs) regulating DLAT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DLAT	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
DLAT	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DLAT	jaspar__MA1483.2	ELF2 (directAnnotation).
DLAT	swissregulon__hs__ETV6	ETV6 (directAnnotation).
DLAT	transfac_pro__M04826	EP300 (directAnnotation).
DLAT	transfac_pro__M04794	TAF1 (directAnnotation).
DLAT	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
DLAT	"Dihydrolipoic Acid"	DB03760	small molecule
DLAT	"NADH"	DB00157	small molecule
DLAT	"Radicicol"	DB03758	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."