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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DKK1

Summary for DKK1

Gene information	Gene symbol	DKK1
	Ensembl ID	ENSG00000107984
	Entrez ID	22943
	Gene name	dickkopf WNT signaling pathway inhibitor 1
	Synonyms	DKK-1\|SK
	Gene type	protein_coding
	UniProtAcc	O94907

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Dataset with differentially expressed gene: DKK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.580968	1.11e-16
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.19517	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.36827	3.14e-05
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.362919	4.37e-07
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.778567	7.28e-21
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	1.06531	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.07234	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.25841	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.626866	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.736856	0.00e+00

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Expression of DKK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DKK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
DKK1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating DKK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DKK1	hsa-miR-493-3p	94.7759	NM_012242
DKK1	hsa-miR-433-3p	94.6837	NM_012242
DKK1	hsa-miR-4511	93.9691	NM_012242
DKK1	hsa-miR-3658	93.624	NM_012242
DKK1	hsa-miR-1227-3p	92.6601	NM_012242
DKK1	hsa-miR-4503	92.0439	NM_012242
DKK1	hsa-miR-3177-5p	90.328	NM_012242
DKK1	hsa-miR-4699-3p	85.2981	NM_012242
DKK1	hsa-miR-4282	83.8149	NM_012242
DKK1	hsa-miR-3065-3p	83.103	NM_012242
DKK1	hsa-miR-126-5p	83.0884	NM_012242
DKK1	hsa-miR-1912-5p	80.1132	NM_012242

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Motifs and transcription factors (TFs) regulating DKK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DKK1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
DKK1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
DKK1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
DKK1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
DKK1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DKK1	transfac_pro__M00652	NRF1 (directAnnotation).
DKK1	transfac_pro__M04866	HDAC2 (directAnnotation).
DKK1	transfac_pro__M06660	ZNF670 (directAnnotation).
DKK1	transfac_pro__M05349	SNAI3 (directAnnotation).
DKK1	transfac_pro__M04722	SPI1 (directAnnotation).
DKK1	metacluster_135.11	NR2C2 (directAnnotation).
DKK1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DKK1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DKK1	metacluster_198.3	ZFP64 (directAnnotation).
DKK1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DKK1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DKK1	metacluster_175.1	ZNF283 (directAnnotation).
DKK1	hdpi__ZNF304	ZNF304 (directAnnotation).
DKK1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DKK1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DKK1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
DKK1	transfac_pro__M04826	EP300 (directAnnotation).
DKK1	cisbp__M02645	ETS1 (directAnnotation).
DKK1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
DKK1	taipale_tf_pairs__MYBL1_MAX_YAACGGNNNNNNNNNNCACGTG_CAP_repr	MAX; MYBL1 (directAnnotation).
DKK1	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
DKK1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
DKK1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
DKK1	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
DKK1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
DKK1	metacluster_22.13	MAFK (inferredBy_Orthology).
DKK1	transfac_pro__M06181	ZNF165 (directAnnotation).
DKK1	taipale_tf_pairs__TEAD4_CLOCK_GGWATGNNNNNNNCACGTGN_CAP_repr	CLOCK; TEAD4 (directAnnotation).
DKK1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
DKK1	transfac_pro__M01299	MECP2 (directAnnotation).
DKK1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."