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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DIP2A

Summary for DIP2A

Gene information	Gene symbol	DIP2A
	Ensembl ID	ENSG00000160305
	Entrez ID	23181
	Gene name	disco interacting protein 2 homolog A
	Synonyms	C21orf106\|Dip2\|KIAA0184
	Gene type	protein_coding
	UniProtAcc	Q14689

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Dataset with differentially expressed gene: DIP2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.55378	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.279858	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.287357	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.291718	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.290845	1.03e-21
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.329461	0.00e+00

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Expression of DIP2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DIP2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DIP2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DIP2A	hsa-miR-5692a	99.5239	NM_001146116
DIP2A	hsa-miR-3163	98.1892	NM_001146116
DIP2A	hsa-miR-590-3p	97.1713	NM_001146116
DIP2A	hsa-miR-3160-5p	96.9522	NM_001146116
DIP2A	hsa-miR-10395-3p	96.6514	NM_206889
DIP2A	hsa-miR-505-3p	94.9005	NM_001146116
DIP2A	hsa-miR-106a-3p	93.8979	NM_206889
DIP2A	hsa-miR-548c-3p	91.9074	NM_001146116
DIP2A	hsa-miR-548s	90.7533	NM_001146116
DIP2A	hsa-miR-4775	90.3552	NM_001146116
DIP2A	hsa-miR-548e-5p	89.7239	NM_001146116
DIP2A	hsa-miR-3689b-5p	89.3504	NM_001146116
DIP2A	hsa-miR-3689f	89.3504	NM_001146116
DIP2A	hsa-miR-3689e	89.3504	NM_001146116
DIP2A	hsa-miR-3689a-5p	89.3504	NM_001146116
DIP2A	hsa-miR-4319	89.1773	NM_001146116
DIP2A	hsa-miR-4477a	87.6814	NM_001146116
DIP2A	hsa-miR-10527-5p	87.4057	NM_001146116
DIP2A	hsa-miR-224-3p	87.2844	NM_206891
DIP2A	hsa-miR-522-3p	87.2844	NM_206891
DIP2A	hsa-miR-125b-5p	86.4099	NM_001146116
DIP2A	hsa-miR-125a-5p	86.4099	NM_001146116
DIP2A	hsa-miR-5585-3p	86.0723	NM_206891
DIP2A	hsa-miR-196b-5p	85.3586	NM_001146116
DIP2A	hsa-miR-196a-5p	85.3586	NM_001146116
DIP2A	hsa-miR-4423-3p	85.2073	NM_001146116
DIP2A	hsa-miR-524-5p	84.7251	NM_001146116
DIP2A	hsa-miR-520d-5p	84.7251	NM_001146116
DIP2A	hsa-miR-4500	84.3226	NM_001146116
DIP2A	hsa-miR-183-5p	84.091	NM_001146116
DIP2A	hsa-miR-519b-3p	83.6919	NM_001146116
DIP2A	hsa-miR-519a-3p	83.6919	NM_001146116
DIP2A	hsa-miR-519c-3p	83.6919	NM_001146116
DIP2A	hsa-let-7i-5p	81.7339	NM_001146116
DIP2A	hsa-let-7f-5p	81.7339	NM_001146116
DIP2A	hsa-let-7b-5p	81.7339	NM_001146116
DIP2A	hsa-let-7a-5p	81.7339	NM_001146116
DIP2A	hsa-let-7g-5p	81.7339	NM_001146116
DIP2A	hsa-let-7c-5p	81.7339	NM_001146116
DIP2A	hsa-miR-4458	81.7339	NM_001146116
DIP2A	hsa-let-7d-5p	81.7339	NM_001146116
DIP2A	hsa-miR-98-5p	81.7339	NM_001146116
DIP2A	hsa-let-7e-5p	81.7339	NM_001146116
DIP2A	hsa-miR-4777-5p	81.7234	NM_001146116
DIP2A	hsa-miR-5582-5p	81.0474	NM_001146116
DIP2A	hsa-miR-4257	80.6362	NM_001146116
DIP2A	hsa-miR-493-5p	80.4968	NM_001146116

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Motifs and transcription factors (TFs) regulating DIP2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DIP2A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DIP2A	transfac_pro__M05479	ZNF580 (directAnnotation).
DIP2A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DIP2A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DIP2A	jaspar__MA0079.5	SP1 (directAnnotation).
DIP2A	transfac_pro__M04826	EP300 (directAnnotation).
DIP2A	transfac_pro__M06864	ZNF585B (directAnnotation).
DIP2A	metacluster_198.3	ZFP64 (directAnnotation).
DIP2A	cisbp__M00968	MTF2 (directAnnotation).
DIP2A	transfac_pro__M00716	ZBTB14 (directAnnotation).
DIP2A	transfac_pro__M02089	E2F3 (directAnnotation).
DIP2A	transfac_pro__M04817	ZBTB33 (directAnnotation).
DIP2A	transfac_pro__M07310	SP5 (directAnnotation).
DIP2A	hdpi__NRL	NRL (directAnnotation).
DIP2A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
DIP2A	hdpi__HIP2	UBE2K (directAnnotation).
DIP2A	transfac_pro__M07387	ZBTB7A (directAnnotation).
DIP2A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DIP2A	transfac_pro__M01783	SP2 (directAnnotation).
DIP2A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DIP2A	cisbp__M07938	E2F1 (directAnnotation).
DIP2A	tfdimers__MD00483	ZBTB14 (directAnnotation).
DIP2A	hdpi__GTF3C2	GTF3C2 (directAnnotation).
DIP2A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
DIP2A	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
DIP2A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DIP2A	transfac_pro__M03806	ZBTB7C (directAnnotation).
DIP2A	hdpi__ZNF304	ZNF304 (directAnnotation).
DIP2A	metacluster_135.11	NR2C2 (directAnnotation).
DIP2A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DIP2A	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DIP2A	cisbp__M00343	PAX6 (directAnnotation).
DIP2A	transfac_pro__M12697	ZNF142 (directAnnotation).
DIP2A	transfac_pro__M00938	E2F1 (directAnnotation).
DIP2A	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
DIP2A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DIP2A	transfac_pro__M12694	ZFP14 (directAnnotation).
DIP2A	transfac_pro__M01253	CNOT3 (directAnnotation).
DIP2A	transfac_pro__M04617	ZBTB7A (directAnnotation).
DIP2A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DIP2A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DIP2A	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
DIP2A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DIP2A	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."