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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DIO2

Summary for DIO2

Gene information	Gene symbol	DIO2
	Ensembl ID	ENSG00000211448
	Entrez ID	1734
	Gene name	iodothyronine deiodinase 2
	Synonyms	SELENOY\|SelY\|TXDI2
	Gene type	protein_coding
	UniProtAcc	Q92813

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Dataset with differentially expressed gene: DIO2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.556433	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.459136	1.14e-22
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.607527	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.660272	0.00e+00

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Expression of DIO2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DIO2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DIO2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DIO2	hsa-miR-5011-5p	99.6581	NM_000793
DIO2	hsa-miR-190a-3p	99.1999	NM_000793
DIO2	hsa-miR-297	94.7258	NM_000793
DIO2	hsa-miR-3065-3p	94.3411	NM_000793
DIO2	hsa-miR-6881-3p	94.2395	NM_000793
DIO2	hsa-miR-6830-3p	94.2103	NM_000793
DIO2	hsa-miR-6875-3p	92.5903	NM_000793
DIO2	hsa-miR-1264	92.3244	NM_000793
DIO2	hsa-miR-410-3p	92.0414	NM_000793
DIO2	hsa-miR-6807-5p	90.5544	NM_000793
DIO2	hsa-miR-1915-5p	90.4403	NM_000793
DIO2	hsa-miR-4797-3p	90.3351	NM_000793
DIO2	hsa-miR-487a-5p	88.1919	NM_000793
DIO2	hsa-miR-487b-5p	88.1919	NM_000793
DIO2	hsa-miR-29c-3p	88.1143	NM_000793
DIO2	hsa-miR-29a-3p	88.1143	NM_000793
DIO2	hsa-miR-29b-3p	88.1143	NM_000793
DIO2	hsa-miR-4659a-3p	88.017	NM_000793
DIO2	hsa-miR-4659b-3p	88.017	NM_000793
DIO2	hsa-miR-4277	87.3897	NM_000793
DIO2	hsa-miR-877-3p	86.0214	NM_000793
DIO2	hsa-miR-130b-5p	85.2267	NM_000793
DIO2	hsa-miR-142-5p	85.1446	NM_000793
DIO2	hsa-miR-5590-3p	85.1446	NM_000793
DIO2	hsa-miR-5696	84.8843	NM_000793
DIO2	hsa-miR-4299	84.8461	NM_000793
DIO2	hsa-miR-12126	83.8824	NM_000793
DIO2	hsa-miR-4789-3p	83.3868	NM_000793
DIO2	hsa-miR-302f	82.9215	NM_000793
DIO2	hsa-miR-627-3p	82.634	NM_000793
DIO2	hsa-miR-4711-5p	82.456	NM_000793
DIO2	hsa-miR-6872-3p	82.1258	NM_000793
DIO2	hsa-miR-548c-3p	81.6498	NM_000793
DIO2	hsa-miR-3184-3p	81.3483	NM_000793
DIO2	hsa-miR-1251-3p	80.9556	NM_000793
DIO2	hsa-miR-1267	80.8501	NM_000793
DIO2	hsa-miR-6869-5p	80.6317	NM_000793
DIO2	hsa-miR-664b-3p	80.2461	NM_000793
DIO2	hsa-miR-579-3p	80.2461	NM_000793

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Motifs and transcription factors (TFs) regulating DIO2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DIO2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
DIO2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
DIO2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
DIO2	hdpi__TP73	TP73 (directAnnotation).
DIO2	transfac_pro__M06135	ZNF28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."