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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DIAPH1

Summary for DIAPH1

Gene information	Gene symbol	DIAPH1
	Ensembl ID	ENSG00000131504
	Entrez ID	1729
	Gene name	diaphanous related formin 1
	Synonyms	DFNA1\|hDIA1\|LFHL1\|mDia1
	Gene type	protein_coding
	UniProtAcc	O60610

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Dataset with differentially expressed gene: DIAPH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.31608	2.15e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.355009	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.3373	7.81e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.291773	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.311848	3.02e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.265901	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.517139	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.429786	2.65e-31

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Expression of DIAPH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DIAPH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DIAPH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DIAPH1	hsa-miR-548f-5p	96.6562	NM_001314007
DIAPH1	hsa-miR-548g-5p	96.6562	NM_001314007
DIAPH1	hsa-miR-548x-5p	96.6562	NM_001314007
DIAPH1	hsa-miR-548aj-5p	96.6562	NM_001314007
DIAPH1	hsa-miR-6840-3p	96.4303	NM_001079812
DIAPH1	hsa-miR-7110-3p	95.8373	NM_001079812
DIAPH1	hsa-miR-548p	91.3469	NM_001314007
DIAPH1	hsa-miR-376a-2-5p	91.1728	NM_001079812
DIAPH1	hsa-miR-3714	90.7104	NM_001314007
DIAPH1	hsa-miR-335-3p	89.5571	NM_001079812
DIAPH1	hsa-miR-130a-5p	89.4664	NM_001079812
DIAPH1	hsa-miR-7162-5p	89.296	NM_001314007
DIAPH1	hsa-miR-516a-3p	89.296	NM_001314007
DIAPH1	hsa-miR-516b-3p	89.296	NM_001314007
DIAPH1	hsa-miR-6851-5p	89.2944	NM_001079812
DIAPH1	hsa-miR-1266-5p	88.6881	NM_001079812
DIAPH1	hsa-miR-4690-5p	88.0791	NM_001314007
DIAPH1	hsa-miR-3918	87.5383	NM_001079812
DIAPH1	hsa-miR-92a-2-5p	87.3617	NM_001079812
DIAPH1	hsa-miR-4518	87.3376	NM_001079812
DIAPH1	hsa-miR-2278	87.1604	NM_001314007
DIAPH1	hsa-miR-3689d	85.9986	NM_001079812
DIAPH1	hsa-miR-4323	84.5668	NM_001314007
DIAPH1	hsa-miR-4731-5p	84.3611	NM_001079812
DIAPH1	hsa-miR-147b-5p	83.436	NM_001079812
DIAPH1	hsa-miR-4492	82.9803	NM_001314007
DIAPH1	hsa-miR-2355-5p	82.432	NM_001079812
DIAPH1	hsa-miR-4261	82.3698	NM_001079812
DIAPH1	hsa-miR-485-3p	81.0267	NM_001079812
DIAPH1	hsa-miR-539-3p	81.0267	NM_001079812
DIAPH1	hsa-miR-548e-5p	80.997	NM_001314007

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Motifs and transcription factors (TFs) regulating DIAPH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DIAPH1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DIAPH1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DIAPH1	hdpi__ETV4	ETV4 (directAnnotation).
DIAPH1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DIAPH1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DIAPH1	jaspar__MA0079.5	SP1 (directAnnotation).
DIAPH1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
DIAPH1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
DIAPH1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
DIAPH1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
DIAPH1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
DIAPH1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DIAPH1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DIAPH1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
DIAPH1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DIAPH1	jaspar__MA1122.1	TFDP1 (directAnnotation).
DIAPH1	metacluster_135.11	NR2C2 (directAnnotation).
DIAPH1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DIAPH1	cisbp__M00968	MTF2 (directAnnotation).
DIAPH1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DIAPH1	cisbp__M00341	PAX6 (directAnnotation).
DIAPH1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DIAPH1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DIAPH1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DIAPH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DIAPH1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DIAPH1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DIAPH1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DIAPH1	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
DIAPH1	transfac_pro__M05708	ZNF136 (directAnnotation).
DIAPH1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DIAPH1	transfac_pro__M01122	ZNF219 (directAnnotation).
DIAPH1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DIAPH1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
DIAPH1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
DIAPH1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
DIAPH1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DIAPH1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
DIAPH1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
DIAPH1	metacluster_84.2	RARA (directAnnotation).
DIAPH1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DIAPH1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DIAPH1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DIAPH1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
DIAPH1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
DIAPH1	tfdimers__MD00391	KLF4 (directAnnotation).
DIAPH1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
DIAPH1	transfac_pro__M01973	PLAG1 (directAnnotation).
DIAPH1	transfac_pro__M12697	ZNF142 (directAnnotation).
DIAPH1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."