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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DHX38

Summary for DHX38

Gene information	Gene symbol	DHX38
	Ensembl ID	ENSG00000140829
	Entrez ID	9785
	Gene name	DEAH-box helicase 38
	Synonyms	DDX38\|hPrp16\|KIAA0224\|PRP16\|PRPF16
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DHX38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of DHX38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DHX38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DHX38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DHX38	hsa-miR-4457	94.1464	NM_014003
DHX38	hsa-miR-1976	89.5924	NM_014003
DHX38	hsa-miR-1245b-3p	88.7943	NM_014003
DHX38	hsa-miR-3140-5p	84.6885	NM_014003
DHX38	hsa-miR-4801	82.8426	NM_014003
DHX38	hsa-miR-4258	82.484	NM_014003
DHX38	hsa-miR-4731-3p	81.3677	NM_014003

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Motifs and transcription factors (TFs) regulating DHX38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DHX38	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNYAATTA_CAP	DLX3; ETV2 (directAnnotation).
DHX38	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
DHX38	transfac_pro__M05501	ZBTB8B (directAnnotation).
DHX38	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
DHX38	transfac_pro__M05655	ZNF705G (directAnnotation).
DHX38	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
DHX38	transfac_pro__M06592	ZNF486 (directAnnotation).
DHX38	transfac_pro__M06776	ZNF214 (directAnnotation).
DHX38	transfac_pro__M06594	ZNF668 (directAnnotation).
DHX38	transfac_pro__M06367	ZNF530 (directAnnotation).
DHX38	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
DHX38	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
DHX38	metacluster_86.2	ZNF45 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."