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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DHCR24

Summary for DHCR24

Gene information	Gene symbol	DHCR24
	Ensembl ID	ENSG00000116133
	Entrez ID	1718
	Gene name	24-dehydrocholesterol reductase
	Synonyms	DCE\|KIAA0018\|seladin-1
	Gene type	protein_coding
	UniProtAcc	Q15392

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Dataset with differentially expressed gene: DHCR24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.777996	4.49e-42
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.06115	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.16206	0.00e+00

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Expression of DHCR24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DHCR24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
DHCR24	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating DHCR24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DHCR24	hsa-miR-4505	94.4658	NM_014762
DHCR24	hsa-miR-5787	94.4658	NM_014762
DHCR24	hsa-miR-4653-5p	88.3164	NM_014762
DHCR24	hsa-miR-3921	88.3164	NM_014762
DHCR24	hsa-miR-6756-5p	88.1554	NM_014762
DHCR24	hsa-miR-4673	86.5628	NM_014762
DHCR24	hsa-miR-1299	85.3854	NM_014762
DHCR24	hsa-miR-6766-5p	85.0559	NM_014762
DHCR24	hsa-miR-6884-5p	82.7683	NM_014762
DHCR24	hsa-miR-485-5p	82.7683	NM_014762
DHCR24	hsa-miR-4752	82.2188	NM_014762
DHCR24	hsa-miR-4645-5p	81.6948	NM_014762
DHCR24	hsa-miR-6504-5p	80.5266	NM_014762
DHCR24	hsa-miR-3085-3p	80.5266	NM_014762
DHCR24	hsa-miR-3064-5p	80.5266	NM_014762
DHCR24	hsa-miR-96-5p	80.3912	NM_014762

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Motifs and transcription factors (TFs) regulating DHCR24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DHCR24	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
DHCR24	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
DHCR24	cisbp__M08198	ELF1 (directAnnotation).
DHCR24	jaspar__MA1122.1	TFDP1 (directAnnotation).
DHCR24	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
DHCR24	cisbp__M00341	PAX6 (directAnnotation).
DHCR24	jaspar__MA1650.1	ZBTB14 (directAnnotation).
DHCR24	transfac_pro__M03806	ZBTB7C (directAnnotation).
DHCR24	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
DHCR24	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DHCR24	tfdimers__MD00483	ZBTB14 (directAnnotation).
DHCR24	tfdimers__MD00364	WT1 (directAnnotation).
DHCR24	transfac_pro__M04817	ZBTB33 (directAnnotation).
DHCR24	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DHCR24	transfac_pro__M01253	CNOT3 (directAnnotation).
DHCR24	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."