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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DESI1

Summary for DESI1

Gene information	Gene symbol	DESI1
	Ensembl ID	ENSG00000100418
	Entrez ID	27351
	Gene name	desumoylating isopeptidase 1
	Synonyms	D15Wsu75e\|DESI-1\|FAM152B\|POST\|PPPDE2
	Gene type	protein_coding
	UniProtAcc	Q6ICB0

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Dataset with differentially expressed gene: DESI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.268257	5.64e-14
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.571791	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.311601	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.331371	4.20e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.428699	2.20e-20
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.264422	3.56e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.580194	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.387437	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.284993	0.00e+00

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Expression of DESI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DESI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DESI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DESI1	hsa-miR-195-5p	99.6233	NM_015704
DESI1	hsa-miR-15a-5p	99.6233	NM_015704
DESI1	hsa-miR-16-5p	99.6233	NM_015704
DESI1	hsa-miR-15b-5p	99.6233	NM_015704
DESI1	hsa-miR-424-5p	99.3438	NM_015704
DESI1	hsa-miR-6838-5p	99.3438	NM_015704
DESI1	hsa-miR-497-5p	99.3438	NM_015704
DESI1	hsa-miR-4524b-5p	97.2755	NM_015704
DESI1	hsa-miR-4524a-5p	97.2755	NM_015704
DESI1	hsa-miR-518c-5p	97.1998	NM_015704
DESI1	hsa-miR-6762-3p	96.829	NM_015704
DESI1	hsa-miR-4514	96.7663	NM_015704
DESI1	hsa-miR-4692	96.7663	NM_015704
DESI1	hsa-miR-8084	94.7138	NM_015704
DESI1	hsa-miR-6785-5p	94.6437	NM_015704
DESI1	hsa-miR-4728-5p	94.6437	NM_015704
DESI1	hsa-miR-3191-5p	94.1678	NM_015704
DESI1	hsa-miR-7160-5p	94.0901	NM_015704
DESI1	hsa-miR-6791-5p	93.9317	NM_015704
DESI1	hsa-miR-4292	93.9317	NM_015704
DESI1	hsa-miR-651-3p	93.4531	NM_015704
DESI1	hsa-miR-200b-3p	93.0619	NM_015704
DESI1	hsa-miR-429	93.0619	NM_015704
DESI1	hsa-miR-200c-3p	93.0619	NM_015704
DESI1	hsa-miR-1324	91.8436	NM_015704
DESI1	hsa-miR-6734-3p	91.5533	NM_015704
DESI1	hsa-miR-6883-5p	91.0748	NM_015704
DESI1	hsa-miR-149-3p	91.0748	NM_015704
DESI1	hsa-miR-1827	90.3083	NM_015704
DESI1	hsa-miR-659-3p	87.7464	NM_015704
DESI1	hsa-miR-4308	87.0062	NM_015704
DESI1	hsa-miR-4761-3p	86.5866	NM_015704
DESI1	hsa-miR-889-5p	86.0214	NM_015704
DESI1	hsa-miR-875-3p	85.8255	NM_015704
DESI1	hsa-miR-5680	84.9768	NM_015704
DESI1	hsa-miR-4646-5p	84.8767	NM_015704
DESI1	hsa-miR-204-3p	84.8767	NM_015704
DESI1	hsa-miR-369-3p	84.7348	NM_015704
DESI1	hsa-miR-137-3p	84.4476	NM_015704
DESI1	hsa-miR-3163	84.061	NM_015704
DESI1	hsa-miR-1910-3p	83.718	NM_015704
DESI1	hsa-miR-6511a-5p	82.938	NM_015704
DESI1	hsa-miR-3121-3p	82.9137	NM_015704
DESI1	hsa-miR-4297	82.6826	NM_015704
DESI1	hsa-miR-561-5p	81.4383	NM_015704
DESI1	hsa-miR-4474-3p	81.3143	NM_015704
DESI1	hsa-miR-7110-5p	81.1029	NM_015704
DESI1	hsa-miR-6842-5p	81.1029	NM_015704
DESI1	hsa-miR-3714	81.0067	NM_015704
DESI1	hsa-miR-647	80.9662	NM_015704

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Motifs and transcription factors (TFs) regulating DESI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DESI1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DESI1	jaspar__MA1933.1	SREBF2 (directAnnotation).
DESI1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."