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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DERL2

Summary for DERL2

Gene information	Gene symbol	DERL2
	Ensembl ID	ENSG00000072849
	Entrez ID	51009
	Gene name	derlin 2
	Synonyms	CGI-101\|derlin-2\|F-LAN-1\|F-LANa\|FLANa
	Gene type	protein_coding
	UniProtAcc	Q9GZP9

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Dataset with differentially expressed gene: DERL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.269071	2.09e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.350008	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.413392	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.29645	4.12e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.321644	3.39e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.330786	3.84e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.329917	4.00e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.501116	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.292604	2.56e-27

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Expression of DERL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DERL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DERL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DERL2	hsa-miR-4303	96.8464	NM_016041
DERL2	hsa-miR-516b-5p	96.119	NM_001304779
DERL2	hsa-miR-95-5p	95.1626	NM_016041
DERL2	hsa-miR-361-5p	93.9657	NM_001304779
DERL2	hsa-miR-1245b-5p	92.4258	NM_016041
DERL2	hsa-miR-5582-3p	92.418	NM_016041
DERL2	hsa-miR-1299	92.1133	NM_001304779
DERL2	hsa-miR-4782-5p	91.4756	NM_001304779
DERL2	hsa-miR-5706	91.4756	NM_001304779
DERL2	hsa-miR-106b-5p	90.916	NM_001304779
DERL2	hsa-miR-20a-5p	90.916	NM_001304779
DERL2	hsa-miR-6822-3p	90.6858	NM_001304779
DERL2	hsa-miR-6740-3p	90.1817	NM_001304779
DERL2	hsa-miR-3163	89.3476	NM_016041
DERL2	hsa-miR-106a-5p	89.2338	NM_001304779
DERL2	hsa-miR-20b-5p	89.2338	NM_001304779
DERL2	hsa-miR-519d-3p	89.2338	NM_001304779
DERL2	hsa-miR-93-5p	89.2338	NM_001304779
DERL2	hsa-miR-17-5p	89.2338	NM_001304779
DERL2	hsa-miR-526b-3p	89.2338	NM_001304779
DERL2	hsa-miR-760	88.7246	NM_001304779
DERL2	hsa-miR-8057	88.3973	NM_001304779
DERL2	hsa-miR-3142	87.9885	NM_016041
DERL2	hsa-miR-7978	86.8139	NM_001304779
DERL2	hsa-miR-520f-3p	86.6929	NM_001304779
DERL2	hsa-miR-4524a-3p	85.8545	NM_016041
DERL2	hsa-miR-3065-3p	84.4608	NM_001304779
DERL2	hsa-miR-4470	82.742	NM_016041
DERL2	hsa-miR-3165	82.6225	NM_016041
DERL2	hsa-miR-6752-3p	81.9458	NM_016041
DERL2	hsa-miR-4682	81.8383	NM_016041
DERL2	hsa-miR-3928-3p	81.8062	NM_001304779
DERL2	hsa-miR-4796-3p	81.7608	NM_001304779
DERL2	hsa-miR-4708-5p	81.742	NM_001304779
DERL2	hsa-miR-6852-3p	81.6676	NM_016041
DERL2	hsa-miR-3915	81.0513	NM_001304779
DERL2	hsa-miR-3613-3p	80.6224	NM_001304779
DERL2	hsa-miR-587	80.3685	NM_016041
DERL2	hsa-miR-302e	80.3054	NM_001304779

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Motifs and transcription factors (TFs) regulating DERL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DERL2	cisbp__M00808	MYPOP (inferredBy_Orthology).
DERL2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
DERL2	jaspar__MA1967.1	TFAP4 (directAnnotation).
DERL2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
DERL2	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."