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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DERL1

Summary for DERL1

Gene information	Gene symbol	DERL1
	Ensembl ID	ENSG00000136986
	Entrez ID	79139
	Gene name	derlin 1
	Synonyms	DER-1\|DER1\|derlin-1\|FLJ13784\|MGC3067\|PRO2577
	Gene type	protein_coding
	UniProtAcc	Q9BUN8

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Dataset with differentially expressed gene: DERL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.479237	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.286607	2.09e-03
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.31171	1.74e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.41313	1.67e-17
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.434607	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.322378	2.77e-15

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Expression of DERL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DERL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DERL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DERL1	hsa-miR-98-3p	92.8431	NM_001134671
DERL1	hsa-let-7a-3p	92.8431	NM_001134671
DERL1	hsa-let-7b-3p	92.8431	NM_001134671
DERL1	hsa-let-7f-1-3p	92.8431	NM_001134671
DERL1	hsa-miR-7106-5p	92.8047	NM_001134671
DERL1	hsa-miR-4447	91.8641	NM_024295
DERL1	hsa-miR-541-5p	91.2932	NM_024295
DERL1	hsa-miR-4311	90.6963	NM_001134671
DERL1	hsa-miR-12136	89.9375	NM_001134671
DERL1	hsa-miR-9900	89.6247	NM_024295
DERL1	hsa-miR-95-5p	89.357	NM_001134671
DERL1	hsa-miR-4262	89.249	NM_024295
DERL1	hsa-miR-6739-3p	89.2247	NM_001134671
DERL1	hsa-miR-548as-3p	88.4389	NM_024295
DERL1	hsa-miR-4698	88.3961	NM_024295
DERL1	hsa-miR-19b-1-5p	87.4506	NM_024295
DERL1	hsa-miR-19a-5p	87.4506	NM_024295
DERL1	hsa-miR-19b-2-5p	87.4506	NM_024295
DERL1	hsa-miR-4677-5p	87.0279	NM_001134671
DERL1	hsa-miR-4472	86.8015	NM_024295
DERL1	hsa-miR-3613-3p	85.6055	NM_024295
DERL1	hsa-miR-181b-5p	84.8429	NM_024295
DERL1	hsa-miR-181a-5p	84.8429	NM_024295
DERL1	hsa-miR-181c-5p	84.8429	NM_024295
DERL1	hsa-miR-181d-5p	84.8429	NM_024295
DERL1	hsa-miR-3662	84.7858	NM_024295
DERL1	hsa-miR-7108-5p	81.5907	NM_024295
DERL1	hsa-miR-5586-5p	81.1388	NM_024295
DERL1	hsa-miR-6780a-5p	81.1154	NM_001134671
DERL1	hsa-miR-6759-5p	80.5217	NM_024295

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Motifs and transcription factors (TFs) regulating DERL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DERL1	transfac_pro__M04746	E2F1 (directAnnotation).
DERL1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
DERL1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
DERL1	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
DERL1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
DERL1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
DERL1	transfac_pro__M04918	EGR1 (directAnnotation).
DERL1	metacluster_182.10	ZFX (directAnnotation).
DERL1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DERL1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
DERL1	hdpi__TIMELESS	TIMELESS (directAnnotation).
DERL1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
DERL1	hdpi__TP73	TP73 (directAnnotation).
DERL1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
DERL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DERL1	hdpi__ELF2	ELF2 (directAnnotation).
DERL1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
DERL1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
DERL1	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
DERL1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
DERL1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
DERL1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
DERL1	hdpi__ETV4	ETV4 (directAnnotation).
DERL1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
DERL1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
DERL1	jaspar__MA1708.1	ETV7 (directAnnotation).
DERL1	metacluster_183.4	ETS1 (inferredBy_Orthology).
DERL1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
DERL1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
DERL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DERL1	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."