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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DENND6A

Summary for DENND6A

Gene information	Gene symbol	DENND6A
	Ensembl ID	ENSG00000174839
	Entrez ID	201627
	Gene name	DENN domain containing 6A
	Synonyms	AFI1A\|FAM116A\|FLJ34969
	Gene type	protein_coding
	UniProtAcc	Q8IWF6

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Dataset with differentially expressed gene: DENND6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.274104	0.00e+00

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Expression of DENND6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DENND6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DENND6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DENND6A	hsa-miR-510-3p	98.8285	NM_152678
DENND6A	hsa-miR-5692a	97.0871	NM_152678
DENND6A	hsa-miR-494-3p	96.3263	NM_152678
DENND6A	hsa-miR-532-5p	95.9239	NM_152678
DENND6A	hsa-miR-124-3p	95.8828	NM_152678
DENND6A	hsa-miR-506-3p	95.8828	NM_152678
DENND6A	hsa-miR-4531	94.925	NM_152678
DENND6A	hsa-miR-1305	94.8372	NM_152678
DENND6A	hsa-miR-16-1-3p	94.795	NM_152678
DENND6A	hsa-miR-19a-3p	94.1531	NM_152678
DENND6A	hsa-miR-19b-3p	94.1531	NM_152678
DENND6A	hsa-miR-4451	92.5756	NM_152678
DENND6A	hsa-miR-203a-3p	92.0878	NM_152678
DENND6A	hsa-miR-29c-3p	91.6836	NM_152678
DENND6A	hsa-miR-29b-3p	91.6836	NM_152678
DENND6A	hsa-miR-29a-3p	91.6836	NM_152678
DENND6A	hsa-miR-140-3p	91.5038	NM_152678
DENND6A	hsa-miR-938	90.0483	NM_152678
DENND6A	hsa-miR-3065-3p	89.9196	NM_152678
DENND6A	hsa-miR-1468-3p	89.8111	NM_152678
DENND6A	hsa-miR-3144-3p	89.4802	NM_152678
DENND6A	hsa-miR-4719	88.8996	NM_152678
DENND6A	hsa-miR-1245b-5p	88.491	NM_152678
DENND6A	hsa-miR-3142	88.491	NM_152678
DENND6A	hsa-miR-548n	88.0904	NM_152678
DENND6A	hsa-miR-6809-5p	87.8915	NM_152678
DENND6A	hsa-miR-6815-3p	87.4846	NM_152678
DENND6A	hsa-miR-153-5p	86.9838	NM_152678
DENND6A	hsa-let-7c-3p	86.8563	NM_152678
DENND6A	hsa-miR-126-5p	86.6369	NM_152678
DENND6A	hsa-miR-196a-5p	86.3689	NM_152678
DENND6A	hsa-miR-196b-5p	86.3689	NM_152678
DENND6A	hsa-miR-6895-3p	85.6288	NM_152678
DENND6A	hsa-miR-2116-5p	85.6088	NM_152678
DENND6A	hsa-miR-4302	85.5341	NM_152678
DENND6A	hsa-miR-6873-3p	85.336	NM_152678
DENND6A	hsa-miR-7977	85.2049	NM_152678
DENND6A	hsa-miR-3163	85.1472	NM_152678
DENND6A	hsa-miR-605-3p	84.9761	NM_152678
DENND6A	hsa-miR-4652-3p	84.7661	NM_152678
DENND6A	hsa-miR-509-3-5p	84.5884	NM_152678
DENND6A	hsa-miR-509-5p	84.5884	NM_152678
DENND6A	hsa-miR-105-5p	84.4734	NM_152678
DENND6A	hsa-miR-7853-5p	84.4734	NM_152678
DENND6A	hsa-miR-1197	84.2314	NM_152678
DENND6A	hsa-miR-3202	84.0591	NM_152678
DENND6A	hsa-miR-125a-5p	84.023	NM_152678
DENND6A	hsa-miR-4319	84.023	NM_152678
DENND6A	hsa-miR-199b-5p	83.9837	NM_152678
DENND6A	hsa-miR-199a-5p	83.9837	NM_152678

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Motifs and transcription factors (TFs) regulating DENND6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DENND6A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
DENND6A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DENND6A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DENND6A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
DENND6A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DENND6A	metacluster_151.2	ZNF23 (directAnnotation).
DENND6A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
DENND6A	transfac_pro__M01199	TRIM28 (directAnnotation).
DENND6A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
DENND6A	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
DENND6A	transfac_pro__M01253	CNOT3 (directAnnotation).
DENND6A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
DENND6A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
DENND6A	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
DENND6A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DENND6A	metacluster_7.13	ZFX (directAnnotation).
DENND6A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
DENND6A	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
DENND6A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DENND6A	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
DENND6A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DENND6A	transfac_pro__M00938	E2F1 (directAnnotation).
DENND6A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DENND6A	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
DENND6A	transfac_pro__M12697	ZNF142 (directAnnotation).
DENND6A	metacluster_175.1	ZNF283 (directAnnotation).
DENND6A	cisbp__M00788	ZFY (inferredBy_Orthology).
DENND6A	tfdimers__MD00364	WT1 (directAnnotation).
DENND6A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
DENND6A	hdpi__ZNF304	ZNF304 (directAnnotation).
DENND6A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DENND6A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DENND6A	tfdimers__MD00483	ZBTB14 (directAnnotation).
DENND6A	metacluster_198.3	ZFP64 (directAnnotation).
DENND6A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DENND6A	transfac_pro__M01303	SP1 (directAnnotation).
DENND6A	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
DENND6A	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
DENND6A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DENND6A	metacluster_144.13	HIC1; HIC1 (directAnnotation).
DENND6A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DENND6A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DENND6A	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
DENND6A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DENND6A	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
DENND6A	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
DENND6A	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
DENND6A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DENND6A	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
DENND6A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."