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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DENND5A

Summary for DENND5A

Gene information	Gene symbol	DENND5A
	Ensembl ID	ENSG00000184014
	Entrez ID	23258
	Gene name	DENN domain containing 5A
	Synonyms	FLJ22354\|FLJ33829\|FLJ43455\|KIAA1091\|RAB6IP1
	Gene type	protein_coding
	UniProtAcc	Q6IQ26

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Dataset with differentially expressed gene: DENND5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.326689	1.55e-28

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Expression of DENND5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DENND5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DENND5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DENND5A	hsa-miR-4803	99.5233	NM_001243254
DENND5A	hsa-miR-575	96.8539	NM_001243254
DENND5A	hsa-miR-4676-5p	96.8539	NM_001243254
DENND5A	hsa-miR-888-3p	95.9256	NM_001243254
DENND5A	hsa-miR-103b	95.0904	NM_001243254
DENND5A	hsa-miR-520f-5p	95.0294	NM_015213
DENND5A	hsa-miR-3934-5p	94.6732	NM_015213
DENND5A	hsa-miR-2053	94.3758	NM_015213
DENND5A	hsa-miR-5692a	93.3119	NM_001243254
DENND5A	hsa-miR-6858-3p	92.1137	NM_001243254
DENND5A	hsa-miR-548c-3p	91.2162	NM_015213
DENND5A	hsa-miR-409-3p	90.987	NM_001243254
DENND5A	hsa-miR-33a-3p	90.987	NM_001243254
DENND5A	hsa-miR-130b-5p	90.0669	NM_015213
DENND5A	hsa-miR-561-5p	89.3378	NM_001243254
DENND5A	hsa-miR-595	88.5067	NM_001243254
DENND5A	hsa-miR-6508-3p	88.1698	NM_015213
DENND5A	hsa-miR-429	87.9758	NM_001243254
DENND5A	hsa-miR-200b-3p	87.9758	NM_001243254
DENND5A	hsa-miR-200c-3p	87.9758	NM_001243254
DENND5A	hsa-miR-495-5p	87.8322	NM_015213
DENND5A	hsa-miR-450a-1-3p	87.8149	NM_015213
DENND5A	hsa-miR-618	87.3111	NM_015213
DENND5A	hsa-miR-545-3p	86.3559	NM_015213
DENND5A	hsa-miR-4263	85.6101	NM_015213
DENND5A	hsa-miR-4684-3p	85.4841	NM_015213
DENND5A	hsa-miR-3121-3p	85.0835	NM_001243254
DENND5A	hsa-miR-1183	84.8568	NM_015213
DENND5A	hsa-miR-1184	84.386	NM_001243254
DENND5A	hsa-miR-1976	82.8326	NM_001243254
DENND5A	hsa-miR-493-5p	81.1855	NM_001243254

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Motifs and transcription factors (TFs) regulating DENND5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DENND5A	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
DENND5A	jaspar__MA0502.2	NFYB (directAnnotation).
DENND5A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DENND5A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DENND5A	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
DENND5A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DENND5A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DENND5A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."