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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: DEGS1

Summary for DEGS1

Gene informationGene symbol

DEGS1

Ensembl ID

ENSG00000143753

Entrez ID

8560

Gene namedelta 4-desaturase, sphingolipid 1
SynonymsDEGS-1|Des-1|DES1|FADS7|MLD
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: DEGS1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-0.6864487.82e-06

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.2919314.31e-19

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.3480940.00e+00

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-1.519650.00e+00

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells-0.3296845.65e-12

GSE104987

MCF7 cell lineCell lineBreast cancerER+ breast cancerTargeted therapyKDM5-C70NAMalignant cells-0.3171238.88e-20

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells-0.322881.61e-10

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.4246362.90e-39

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Expression of DEGS1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to DEGS1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DEGS1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
DEGS1hsa-miR-208a-5p98.7171NM_003676
DEGS1hsa-miR-208b-5p98.7171NM_003676
DEGS1hsa-miR-6884-3p93.2778NM_001321541
DEGS1hsa-miR-6845-3p92.6558NM_001321541
DEGS1hsa-miR-190a-3p92.4505NM_003676
DEGS1hsa-miR-143-3p91.619NM_003676
DEGS1hsa-miR-477091.619NM_003676
DEGS1hsa-miR-3606-5p90.9656NM_003676
DEGS1hsa-miR-5586-5p90.3469NM_001321541
DEGS1hsa-miR-608889.488NM_003676
DEGS1hsa-miR-428286.7285NM_003676
DEGS1hsa-miR-3680-3p86.1594NM_003676
DEGS1hsa-miR-101-3p85.8915NM_001321541
DEGS1hsa-miR-4714-5p84.9266NM_003676
DEGS1hsa-miR-365b-5p84.7498NM_001321541
DEGS1hsa-miR-365a-5p84.7498NM_001321541
DEGS1hsa-miR-877-3p84.0282NM_001321541
DEGS1hsa-miR-5011-5p82.8895NM_003676
DEGS1hsa-miR-6778-3p81.7415NM_001321541
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Motifs and transcription factors (TFs) regulating DEGS1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
DEGS1metacluster_132.4MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
DEGS1metacluster_135.11NR2C2 (directAnnotation).
DEGS1metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DEGS1metacluster_144.3ZNF704; ZNF704 (directAnnotation).
DEGS1metacluster_7.13ZFX (directAnnotation).
DEGS1cisbp__M00968MTF2 (directAnnotation).
DEGS1metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DEGS1cisbp__M00341PAX6 (directAnnotation).
DEGS1metacluster_198.3ZFP64 (directAnnotation).
DEGS1metacluster_61.1DEAF1; DEAF1 (directAnnotation).
DEGS1cisbp__M00788ZFY (inferredBy_Orthology).
DEGS1hdpi__ZNF304ZNF304 (directAnnotation).
DEGS1metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DEGS1metacluster_151.2ZNF23 (directAnnotation).
DEGS1transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DEGS1transfac_pro__M03806ZBTB7C (directAnnotation).
DEGS1transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DEGS1cisbp__M01863ZNF711 (inferredBy_Orthology).
DEGS1metacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
DEGS1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
DEGS1swissregulon__hs__ELK1ELK1 (directAnnotation).
DEGS1metacluster_81.7CREB1 (directAnnotation).
DEGS1taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_reprETV2; HES7 (directAnnotation).
DEGS1kznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
DEGS1taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAPE2F3; HES7 (directAnnotation).
DEGS1transfac_pro__M02089E2F3 (directAnnotation).
DEGS1taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
DEGS1transfac_pro__M04817ZBTB33 (directAnnotation).
DEGS1transfac_pro__M02861GATA6 (inferredBy_Orthology).
DEGS1tfdimers__MD00483ZBTB14 (directAnnotation).
DEGS1cisbp__M07938E2F1 (directAnnotation).
DEGS1jaspar__MA0535.1SMAD9 (inferredBy_Orthology).
DEGS1taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
DEGS1transfac_pro__M00803E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DEGS1hdpi__NRLNRL (directAnnotation).
DEGS1homer__GGCGGGAARN_E2F6E2F6 (directAnnotation).
DEGS1homer__NANTGCSGCA_Zfp57ZFP57 (directAnnotation).
DEGS1metacluster_197.3E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
DEGS1metacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DEGS1metacluster_3.14WT1; WT1 (directAnnotation).
DEGS1jaspar__MA0748.2YY2 (directAnnotation).
DEGS1transfac_pro__M00716ZBTB14 (directAnnotation).
DEGS1metacluster_67.2ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DEGS1metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DEGS1transfac_pro__M04916TAF1 (directAnnotation).
DEGS1transfac_pro__M00938E2F1 (directAnnotation).
DEGS1transfac_pro__M02090E2F4 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."