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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DDI2

Summary for DDI2

Gene information	Gene symbol	DDI2
	Ensembl ID	ENSG00000197312
	Entrez ID	84301
	Gene name	DNA damage inducible 1 homolog 2
	Synonyms	MGC14844
	Gene type	protein_coding
	UniProtAcc	Q5TDH0

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Dataset with differentially expressed gene: DDI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.27088	1.05e-03

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Expression of DDI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DDI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DDI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DDI2	hsa-miR-4762-3p	94.3746	NM_032341
DDI2	hsa-miR-6071	93.6672	NM_032341
DDI2	hsa-miR-542-3p	93.2922	NM_032341
DDI2	hsa-miR-1267	93.2243	NM_032341
DDI2	hsa-miR-587	92.9246	NM_032341
DDI2	hsa-miR-22-5p	92.2178	NM_032341
DDI2	hsa-miR-93-3p	91.9153	NM_032341
DDI2	hsa-miR-4500	91.4385	NM_032341
DDI2	hsa-let-7a-5p	91.2438	NM_032341
DDI2	hsa-let-7e-5p	91.2438	NM_032341
DDI2	hsa-let-7c-5p	91.2438	NM_032341
DDI2	hsa-miR-98-5p	91.2438	NM_032341
DDI2	hsa-let-7b-5p	91.2438	NM_032341
DDI2	hsa-let-7i-5p	91.2438	NM_032341
DDI2	hsa-let-7g-5p	91.2438	NM_032341
DDI2	hsa-let-7f-5p	91.2438	NM_032341
DDI2	hsa-miR-4778-3p	91.0801	NM_032341
DDI2	hsa-miR-4659a-3p	90.6541	NM_032341
DDI2	hsa-miR-4659b-3p	90.6541	NM_032341
DDI2	hsa-let-7d-5p	89.8776	NM_032341
DDI2	hsa-miR-4458	89.8776	NM_032341
DDI2	hsa-miR-138-1-3p	89.8342	NM_032341
DDI2	hsa-miR-29a-5p	89.3687	NM_032341
DDI2	hsa-miR-1206	88.4103	NM_032341
DDI2	hsa-miR-1305	88.3928	NM_032341
DDI2	hsa-miR-4527	88.0506	NM_032341
DDI2	hsa-miR-3682-5p	86.762	NM_032341
DDI2	hsa-miR-6824-3p	86.7413	NM_032341
DDI2	hsa-miR-6764-3p	86.7413	NM_032341
DDI2	hsa-miR-2116-5p	86.259	NM_032341
DDI2	hsa-miR-627-3p	85.5787	NM_032341
DDI2	hsa-miR-3928-5p	84.6305	NM_032341
DDI2	hsa-miR-6806-3p	84.6305	NM_032341
DDI2	hsa-miR-576-3p	84.4433	NM_032341
DDI2	hsa-miR-1245b-3p	82.4763	NM_032341
DDI2	hsa-miR-4677-5p	81.5804	NM_032341
DDI2	hsa-miR-4782-5p	81.305	NM_032341
DDI2	hsa-miR-5706	81.305	NM_032341
DDI2	hsa-miR-6503-5p	80.8186	NM_032341

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Motifs and transcription factors (TFs) regulating DDI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DDI2	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
DDI2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DDI2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
DDI2	jaspar__MA1122.1	TFDP1 (directAnnotation).
DDI2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DDI2	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."