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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DDHD1

Summary for DDHD1

Gene information	Gene symbol	DDHD1
	Ensembl ID	ENSG00000100523
	Entrez ID	80821
	Gene name	DDHD domain containing 1
	Synonyms	iPLA1alpha\|KIAA1705\|PA-PLA1\|PAPLA1\|SPG28
	Gene type	protein_coding
	UniProtAcc	Q8NEL9

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Dataset with differentially expressed gene: DDHD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.368597	1.39e-28
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.287469	2.95e-03

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Expression of DDHD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DDHD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DDHD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DDHD1	hsa-miR-4251	99.2864	NM_001160147
DDHD1	hsa-miR-539-5p	99.0912	NM_001160147
DDHD1	hsa-miR-6867-5p	98.9064	NM_001160148
DDHD1	hsa-miR-3671	97.9748	NM_001160148
DDHD1	hsa-miR-4303	96.0527	NM_001160147
DDHD1	hsa-miR-4775	94.9207	NM_001160148
DDHD1	hsa-miR-20a-5p	94.2715	NM_001160147
DDHD1	hsa-miR-106b-5p	94.2715	NM_001160147
DDHD1	hsa-miR-590-3p	94.1314	NM_001160148
DDHD1	hsa-miR-576-5p	93.1619	NM_001160148
DDHD1	hsa-miR-335-3p	93.0486	NM_001160148
DDHD1	hsa-miR-4261	92.939	NM_001160148
DDHD1	hsa-miR-519d-3p	91.9655	NM_001160147
DDHD1	hsa-miR-17-5p	91.9655	NM_001160147
DDHD1	hsa-miR-20b-5p	91.9655	NM_001160147
DDHD1	hsa-miR-93-5p	91.9655	NM_001160147
DDHD1	hsa-miR-106a-5p	91.9532	NM_001160147
DDHD1	hsa-miR-526b-3p	91.9532	NM_001160147
DDHD1	hsa-miR-146b-5p	91.1691	NM_001160147
DDHD1	hsa-miR-146a-5p	91.1691	NM_001160147
DDHD1	hsa-miR-7153-5p	91.1691	NM_001160147
DDHD1	hsa-miR-520f-3p	90.9657	NM_001160148
DDHD1	hsa-miR-3689d	90.0461	NM_001160148
DDHD1	hsa-miR-524-5p	89.905	NM_001160147
DDHD1	hsa-miR-520d-5p	89.905	NM_001160147
DDHD1	hsa-miR-302e	89.715	NM_001160148
DDHD1	hsa-miR-12119	89.3648	NM_001160147
DDHD1	hsa-miR-3614-3p	89.2702	NM_001160148
DDHD1	hsa-miR-4778-3p	89.0181	NM_001160148
DDHD1	hsa-miR-3065-3p	88.6972	NM_001160147
DDHD1	hsa-miR-183-5p	87.8835	NM_001160147
DDHD1	hsa-miR-3123	87.4506	NM_001160147
DDHD1	hsa-miR-6851-5p	86.847	NM_001160148
DDHD1	hsa-miR-4796-3p	86.7967	NM_001160147
DDHD1	hsa-miR-302a-3p	86.4641	NM_001160148
DDHD1	hsa-miR-302d-3p	86.4641	NM_001160148
DDHD1	hsa-miR-302c-3p	86.4641	NM_001160148
DDHD1	hsa-miR-302b-3p	86.4641	NM_001160148
DDHD1	hsa-miR-191-5p	86.3527	NM_001160148
DDHD1	hsa-miR-3662	85.8762	NM_001160148
DDHD1	hsa-miR-3191-5p	85.6069	NM_001160148
DDHD1	hsa-miR-302c-5p	85.5593	NM_001160148
DDHD1	hsa-miR-6825-5p	85.472	NM_001160147
DDHD1	hsa-miR-500b-3p	85.2871	NM_001160148
DDHD1	hsa-miR-4803	84.4752	NM_001160148
DDHD1	hsa-miR-627-3p	84.2551	NM_001160148
DDHD1	hsa-miR-7158-3p	84.2152	NM_001160148
DDHD1	hsa-miR-9983-3p	84.1047	NM_001160148
DDHD1	hsa-miR-452-3p	84.0863	NM_001160148
DDHD1	hsa-miR-129-5p	83.8735	NM_001160148

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Motifs and transcription factors (TFs) regulating DDHD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DDHD1	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
DDHD1	transfac_pro__M04861	SIX5 (directAnnotation).
DDHD1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
DDHD1	taipale_tf_pairs__ETV7_NNGGAAGTGCTTCCNN_HT	ETV7 (directAnnotation).
DDHD1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DDHD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DDHD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DDHD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DDHD1	transfac_pro__M12686	ZBTB10 (directAnnotation).
DDHD1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DDHD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DDHD1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DDHD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
DDHD1	transfac_pro__M04617	ZBTB7A (directAnnotation).
DDHD1	metacluster_151.2	ZNF23 (directAnnotation).
DDHD1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DDHD1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DDHD1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
DDHD1	cisbp__M01864	EGR1 (inferredBy_Orthology).
DDHD1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
DDHD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
DDHD1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DDHD1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
DDHD1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
DDHD1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
DDHD1	transfac_pro__M01253	CNOT3 (directAnnotation).
DDHD1	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
DDHD1	cisbp__M00968	MTF2 (directAnnotation).
DDHD1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
DDHD1	transfac_pro__M01199	TRIM28 (directAnnotation).
DDHD1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
DDHD1	metacluster_3.14	WT1; WT1 (directAnnotation).
DDHD1	transfac_pro__M12697	ZNF142 (directAnnotation).
DDHD1	metacluster_84.2	RARA (directAnnotation).
DDHD1	transfac_pro__M01122	ZNF219 (directAnnotation).
DDHD1	transfac_pro__M07387	ZBTB7A (directAnnotation).
DDHD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DDHD1	transfac_pro__M04893	TAF1 (directAnnotation).
DDHD1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DDHD1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
DDHD1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
DDHD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DDHD1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
DDHD1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
DDHD1	transfac_public__M00373	PAX4 (directAnnotation).
DDHD1	transfac_pro__M01714	KLF15 (directAnnotation).
DDHD1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
DDHD1	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
DDHD1	transfac_pro__M00938	E2F1 (directAnnotation).
DDHD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."