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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCX

Summary for DCX

Gene information	Gene symbol	DCX
	Ensembl ID	ENSG00000077279
	Entrez ID	1641
	Gene name	doublecortin
	Synonyms	DBCN\|DC\|LISX\|SCLH\|XLIS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DCX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.306369	0.00e+00

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Expression of DCX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCX	hsa-miR-6867-5p	99.998	NM_000555
DCX	hsa-miR-8485	99.6539	NM_000555
DCX	hsa-miR-539-5p	98.9781	NM_000555
DCX	hsa-miR-12136	98.0639	NM_000555
DCX	hsa-miR-6833-3p	97.7487	NM_000555
DCX	hsa-miR-4768-3p	97.5482	NM_000555
DCX	hsa-miR-629-3p	97.493	NM_000555
DCX	hsa-miR-196a-1-3p	97.0006	NM_000555
DCX	hsa-miR-875-3p	96.8623	NM_000555
DCX	hsa-miR-605-3p	96.5644	NM_000555
DCX	hsa-miR-3941	96.552	NM_000555
DCX	hsa-miR-4768-5p	96.256	NM_000555
DCX	hsa-miR-663b	95.6391	NM_000555
DCX	hsa-miR-4531	95.4968	NM_000555
DCX	hsa-miR-3613-3p	95.186	NM_000555
DCX	hsa-miR-548e-5p	94.6595	NM_000555
DCX	hsa-miR-4773	93.9924	NM_000555
DCX	hsa-miR-7515	93.8479	NM_000555
DCX	hsa-miR-4433a-3p	93.7181	NM_000555
DCX	hsa-miR-651-3p	93.5948	NM_000555
DCX	hsa-miR-4318	93.3724	NM_000555
DCX	hsa-miR-6809-3p	93.1502	NM_000555
DCX	hsa-miR-6879-5p	93.0548	NM_000555
DCX	hsa-miR-4632-5p	93.0168	NM_000555
DCX	hsa-miR-8084	92.92	NM_000555
DCX	hsa-miR-876-5p	92.9083	NM_000555
DCX	hsa-miR-1252-5p	92.4898	NM_000555
DCX	hsa-miR-498-3p	92.4372	NM_000555
DCX	hsa-miR-488-3p	92.3866	NM_000555
DCX	hsa-miR-1301-3p	92.278	NM_000555
DCX	hsa-miR-5047	92.278	NM_000555
DCX	hsa-miR-3125	92.0564	NM_000555
DCX	hsa-miR-340-5p	91.8421	NM_000555
DCX	hsa-miR-513a-5p	91.8377	NM_000555
DCX	hsa-miR-3167	91.811	NM_000555
DCX	hsa-miR-29a-3p	91.5095	NM_000555
DCX	hsa-miR-29c-3p	91.5095	NM_000555
DCX	hsa-miR-29b-3p	91.5095	NM_000555
DCX	hsa-miR-607	90.8244	NM_000555
DCX	hsa-miR-4686	90.7545	NM_000555
DCX	hsa-miR-6859-5p	90.6847	NM_000555
DCX	hsa-miR-3916	90.6847	NM_000555
DCX	hsa-miR-7152-3p	90.6753	NM_000555
DCX	hsa-miR-647	90.599	NM_000555
DCX	hsa-miR-4519	90.3917	NM_000555
DCX	hsa-miR-1468-3p	90.3216	NM_000555
DCX	hsa-miR-9718	90.3088	NM_000555
DCX	hsa-miR-6772-3p	90.2993	NM_000555
DCX	hsa-miR-4436b-3p	90.0438	NM_000555
DCX	hsa-miR-6735-5p	90.0438	NM_000555

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Motifs and transcription factors (TFs) regulating DCX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."