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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCTN4

Summary for DCTN4

Gene information	Gene symbol	DCTN4
	Ensembl ID	ENSG00000132912
	Entrez ID	51164
	Gene name	dynactin subunit 4
	Synonyms	Dyn4\|p62
	Gene type	protein_coding
	UniProtAcc	Q9UJW0

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Dataset with differentially expressed gene: DCTN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.587338	8.58e-03
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.267159	8.62e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.350405	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.287213	3.55e-40

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Expression of DCTN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCTN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCTN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCTN4	hsa-miR-30e-5p	97.2403	NM_001135643
DCTN4	hsa-miR-30c-5p	97.2403	NM_001135643
DCTN4	hsa-miR-30d-5p	97.2403	NM_001135643
DCTN4	hsa-miR-30b-5p	97.2403	NM_001135643
DCTN4	hsa-miR-30a-5p	97.2403	NM_001135643
DCTN4	hsa-miR-3915	92.2999	NM_001135643
DCTN4	hsa-miR-4719	92.0576	NM_016221
DCTN4	hsa-miR-5571-3p	92.0169	NM_016221
DCTN4	hsa-miR-2392	90.611	NM_001135643
DCTN4	hsa-miR-5009-3p	90.1319	NM_016221
DCTN4	hsa-miR-124-3p	89.786	NM_001135643
DCTN4	hsa-miR-506-3p	89.786	NM_001135643
DCTN4	hsa-miR-6864-5p	89.4517	NM_016221
DCTN4	hsa-miR-4646-5p	89.1699	NM_016221
DCTN4	hsa-miR-204-3p	89.1699	NM_016221
DCTN4	hsa-miR-7515	87.0722	NM_016221
DCTN4	hsa-miR-3910	87.0704	NM_001135643
DCTN4	hsa-miR-3714	87.0704	NM_001135643
DCTN4	hsa-miR-4288	86.3404	NM_016221
DCTN4	hsa-miR-151a-3p	85.3806	NM_016221
DCTN4	hsa-miR-4290	85.0103	NM_001135643
DCTN4	hsa-miR-4775	84.852	NM_016221
DCTN4	hsa-miR-5010-3p	84.8218	NM_001135643
DCTN4	hsa-miR-570-3p	83.7451	NM_016221
DCTN4	hsa-miR-4711-3p	83.4634	NM_016221
DCTN4	hsa-miR-7702	82.329	NM_001135643
DCTN4	hsa-miR-4503	82.0412	NM_016221
DCTN4	hsa-miR-4307	81.7528	NM_016221
DCTN4	hsa-miR-649	81.5229	NM_016221
DCTN4	hsa-miR-2276-3p	81.1995	NM_016221
DCTN4	hsa-miR-556-3p	80.9641	NM_016221
DCTN4	hsa-miR-4659a-3p	80.5261	NM_001135643
DCTN4	hsa-miR-4659b-3p	80.5261	NM_001135643
DCTN4	hsa-miR-450a-2-3p	80.4412	NM_016221
DCTN4	hsa-miR-6716-5p	80.0959	NM_016221
DCTN4	hsa-miR-630	80.0271	NM_016221

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Motifs and transcription factors (TFs) regulating DCTN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCTN4	hdpi__ETV4	ETV4 (directAnnotation).
DCTN4	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
DCTN4	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."